Endothelin 3 (human, rat)

Pricing Availability   Qty
Description: Potent vasoconstrictor
Alternative Names: ET-3
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Endothelin 3 (human, rat)

Endothelin 3 (human, rat) is an endogenous neuropeptide and potent vasoconstrictor. Displays selectivity for the putative ETC endothelin receptor.

Technical Data for Endothelin 3 (human, rat)

M. Wt 2643
Formula C121H168N26O33S4
Sequence CTCFTYKDKECVYYCHLDIIW

(Modifications: Disulfide bridges: 1-15, 3-11)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 117399-93-6
PubChem ID 16133809
InChI Key OQGZWNZGVYLIFX-JQWUVQPESA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Endothelin 3 (human, rat)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Endothelin 3 (human, rat)

Certificate of Analysis / Product Datasheet
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References for Endothelin 3 (human, rat)

References are publications that support the biological activity of the product.

Inoue et al (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 86 2863 PMID: 2649896

Servitja et al (1998) Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 124 1728 PMID: 9756390

Yanagisawa and Masaski (1989) Molecular biology and biochemistry of the endothelins. TiPS 10 374 PMID: 2690429


If you know of a relevant reference for Endothelin 3 (human, rat), please let us know.

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Keywords: Endothelin 3 (human, rat), Endothelin 3 (human, rat) supplier, Potent, vasoconstrictor, Endothelin, Non-Selective, ET, Receptors, agonists, ETB, Endothelin3, (human, rat), ET-3, Non-selective, 1162, Tocris Bioscience

1 Citation for Endothelin 3 (human, rat)

Citations are publications that use Tocris products. Selected citations for Endothelin 3 (human, rat) include:

Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607 PMID: 16432510


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