Endothelin 3 (human, rat)

Pricing Availability Delivery Time Qty
Cat.No. 1162 - Endothelin 3 (human, rat) | Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-lle-Ile-Trp | CAS No. 117399-93-6
Description: Potent vasoconstrictor
Alternative Names: ET-3
Datasheet
Citations (1)
Literature

Biological Activity

Endogenous neuropeptide and potent vasoconstrictor. Displays selectivity for the putative ETC endothelin receptor.

Technical Data

M. Wt 2643
Formula C121H168N26O33S4
Sequence CTCFTYKDKECVYYCHLDIIW

(Modifications: Disulfide bridge between 1 - 15, 3 - 11)

Storage Desiccate at -20°C
CAS Number 117399-93-6
PubChem ID 16133809
InChI Key OQGZWNZGVYLIFX-JQWUVQPESA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2643. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.38 mL 1.89 mL 3.78 mL
5 mM 0.08 mL 0.38 mL 0.76 mL
10 mM 0.04 mL 0.19 mL 0.38 mL
50 mM 0.01 mL 0.04 mL 0.08 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Inoue et al (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 86 2863 PMID: 2649896

Servitja et al (1998) Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 124 1728 PMID: 9756390

Yanagisawa and Masaski (1989) Molecular biology and biochemistry of the endothelins. TiPS 10 374 PMID: 2690429


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Keywords: Potent vasoconstrictor Endothelin Non-Selective ET Receptors agonists ETB Endothelin3 (human rat) ET-3 Non-selective Endothelin

1 Citation for Endothelin 3 (human, rat)

Citations are publications that use Tocris products. Selected citations for Endothelin 3 (human, rat) include:

Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607 PMID: 16432510


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Pathways for Endothelin 3 (human, rat)

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