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Endogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors.
(Modifications: Disulfide bridge between 1 - 15, 3 - 11)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in DMSO|
References are publications that support the biological activity of the product.
Inoue et al (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 86 2863 PMID: 2649896
Servitja et al (1998) Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 124 1728 PMID: 9756390
Yanagisawa and Masaski (1989) Molecular biology and biochemistry of the endothelins. TiPS 10 374 PMID: 2690429
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Keywords: Endothelin 2 (human), Endothelin 2 (human) supplier, ETA/ETB, agonist, Endothelin, Non-Selective, ET, Receptors, Endothelin2, (human), ET-2, Non-selective, 1164, Tocris Bioscience
2 Citations for Endothelin 2 (human)
Citations are publications that use Tocris products. Selected citations for Endothelin 2 (human) include:
Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607 PMID: 16432510
Im et al (2019) INN inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun 10 1387 PMID: 30918259
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