DSP-4

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Cat.No. 2958 - DSP-4 | C11H15BrClN.HCl | CAS No. 40616-75-9
Description: Adrenergic neurotoxin
Chemical Name: N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.

Technical Data

M. Wt 313.06
Formula C11H15BrClN.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 40616-75-9
PubChem ID 38533
InChI Key NDDRNRRNYOULND-UHFFFAOYSA-N
Smiles BrC1=CC=CC=C1CN(CC)CCCl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 31.31 100
water 31.31 100

Preparing Stock Solutions

The following data is based on the product molecular weight 313.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.97 mL 31.94 mL
5 mM 0.64 mL 3.19 mL 6.39 mL
10 mM 0.32 mL 1.6 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jaim-Etcheverry and Zieher (1980) DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 188 513 PMID: 7370771

Kawamura et al (2005) Short and long term analysis of heart rate variations in spontaneous hypertensive rats: effect of DSP-4 administration. Biomed.Pharmacother. 59 S203 PMID: 16275495

Haidkind et al (2002) Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N(2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces dopamine release potential in the nucleus accumbens shell in conscious rats. Neurosci.Letts. 332 79 PMID:


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Keywords: DSP-4, supplier, Adrenergic, neurotoxin, Compounds, Adrenoceptors, Receptors, noradrenergic, neurons, neurotoxins, Adrenergic, Related, Compounds, Adrenergic, Related, Compounds, Tocris Bioscience

2 Citations for DSP-4

Citations are publications that use Tocris products. Selected citations for DSP-4 include:

Coura et al (2013) Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex. FASEB J 27 4343 PMID: 23882123

Li et al (2015) Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain. Toxins (Basel) 7 2422 PMID: 26131771


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