Adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 313.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.19 mL||15.97 mL||31.94 mL|
|5 mM||0.64 mL||3.19 mL||6.39 mL|
|10 mM||0.32 mL||1.6 mL||3.19 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References are publications that support the products' biological activity.
Jaim-Etcheverry and Zieher (1980) DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 188 513 PMID: 7370771
Kawamura et al (2005) Short and long term analysis of heart rate variations in spontaneous hypertensive rats: effect of DSP-4 administration. Biomed.Pharmacother. 59 S203 PMID: 16275495
Haidkind et al (2002) Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N(2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces dopamine release potential in the nucleus accumbens shell in conscious rats. Neurosci.Letts. 332 79 PMID:
If you know of a relevant reference for DSP-4, please let us know.
Keywords: DSP-4, supplier, Adrenergic, neurotoxin, Compounds, Adrenoceptors, Receptors, noradrenergic, neurons, neurotoxins, Adrenergic, Related, Compounds, Adrenergic, Related, Compounds, Tocris Bioscience
2 Citations for DSP-4
Citations are publications that use Tocris products. Selected citations for DSP-4 include:
Coura et al (2013) Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex. FASEB J 27 4343 PMID: 23882123
Li et al (2015) Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain. Toxins (Basel) 7 2422 PMID: 26131771
Do you know of a great paper that uses DSP-4 from Tocris? If so please let us know.
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