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Description: Adrenergic neurotoxin
Chemical Name: N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
Purity: ≥98% (HPLC)
Citations (2)
Literature (1)

Biological Activity for DSP-4

DSP-4 is an adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.

Technical Data for DSP-4

M. Wt 313.06
Formula C11H15BrClN.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 40616-75-9
PubChem ID 38533
Smiles BrC1=CC=CC=C1CN(CC)CCCl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DSP-4

Solvent Max Conc. mg/mL Max Conc. mM
water 31.31 100
ethanol 31.31 100

Preparing Stock Solutions for DSP-4

The following data is based on the product molecular weight 313.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.97 mL 31.94 mL
5 mM 0.64 mL 3.19 mL 6.39 mL
10 mM 0.32 mL 1.6 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets for DSP-4

Certificate of Analysis / Product Datasheet
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References for DSP-4

References are publications that support the biological activity of the product.

Jaim-Etcheverry and Zieher (1980) DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 188 513 PMID: 7370771

Kawamura et al (2005) Short and long term analysis of heart rate variations in spontaneous hypertensive rats: effect of DSP-4 administration. Biomed.Pharmacother. 59 S203 PMID: 16275495

Haidkind et al (2002) Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N(2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces DA release potential in the nucleus accumbens shell in conscious rats. Neurosci.Letts. 332 79

If you know of a relevant reference for DSP-4, please let us know.

View Related Products by Target

Keywords: DSP-4, DSP-4 supplier, Adrenergic, neurotoxin, Compounds, Adrenoceptors, Receptors, noradrenergic, neurons, neurotoxins, Related, 2958, Tocris Bioscience

2 Citations for DSP-4

Citations are publications that use Tocris products. Selected citations for DSP-4 include:

Li et al (2015) Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain. Toxins (Basel) 7 2422 PMID: 26131771

Coura et al (2013) Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex. FASEB J 27 4343 PMID: 23882123

Do you know of a great paper that uses DSP-4 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.