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Biological Activity for DSP-4
DSP-4 is an adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.
Technical Data for DSP-4
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DSP-4
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for DSP-4
The following data is based on the product molecular weight 313.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.19 mL||15.97 mL||31.94 mL|
|5 mM||0.64 mL||3.19 mL||6.39 mL|
|10 mM||0.32 mL||1.6 mL||3.19 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References for DSP-4
References are publications that support the biological activity of the product.
Jaim-Etcheverry and Zieher (1980) DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 188 513 PMID: 7370771
Kawamura et al (2005) Short and long term analysis of heart rate variations in spontaneous hypertensive rats: effect of DSP-4 administration. Biomed.Pharmacother. 59 S203 PMID: 16275495
Haidkind et al (2002) Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N(2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces DA release potential in the nucleus accumbens shell in conscious rats. Neurosci.Letts. 332 79
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Keywords: DSP-4, DSP-4 supplier, Adrenergic, neurotoxin, Compounds, Adrenoceptors, Receptors, noradrenergic, neurons, neurotoxins, Related, 2958, Tocris Bioscience
2 Citations for DSP-4
Citations are publications that use Tocris products. Selected citations for DSP-4 include:
Coura et al (2013) Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex. FASEB J 27 4343 PMID: 23882123
Li et al (2015) Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain. Toxins (Basel) 7 2422 PMID: 26131771
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.