(±)-Vesamicol hydrochloride

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Cat.No. 0653 - (±)-Vesamicol hydrochloride | C17H25NO.HCl | CAS No. 120447-62-3
Description: Inhibits ACh transport
Alternative Names: AH 5183
Chemical Name: (±)-trans-2-(4-Phenylpiperidinyl)cyclohexanol hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for (±)-Vesamicol hydrochloride

(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM). Centrally active following systemic administration in vivo.

Compound Libraries for (±)-Vesamicol hydrochloride

(±)-Vesamicol hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (±)-Vesamicol hydrochloride

M. Wt 295.85
Formula C17H25NO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 120447-62-3
PubChem ID 659839
Smiles O[C@@H]1CCCC[C@H]1N(CC3)CCC3C2=CC=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-Vesamicol hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 5.92 20
DMSO 14.79 50 with gentle warming

Preparing Stock Solutions for (±)-Vesamicol hydrochloride

The following data is based on the product molecular weight 295.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.76 mL 33.8 mL 67.6 mL
2.5 mM 1.35 mL 6.76 mL 13.52 mL
5 mM 0.68 mL 3.38 mL 6.76 mL
25 mM 0.14 mL 0.68 mL 1.35 mL

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Product Datasheets for (±)-Vesamicol hydrochloride

Certificate of Analysis / Product Datasheet
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References for (±)-Vesamicol hydrochloride

References are publications that support the biological activity of the product.

Efange et al (1997) N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J.Med.Chem. 40 3905 PMID: 9397171

Kobayashi et al (1997) Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res.Bull. 43 17 PMID: 9205789

Varoqui and Erickson (1996) Active transport of acetylcholine by the human vesicular acetylcholine transporter. J.Biol.Chem. 271 27229 PMID: 8910293

If you know of a relevant reference for (±)-Vesamicol hydrochloride, please let us know.

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Citations for (±)-Vesamicol hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.