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Biological Activity for (±)-Vesamicol hydrochloride
(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM). Centrally active following systemic administration in vivo.
Compound Libraries for (±)-Vesamicol hydrochloride
Technical Data for (±)-Vesamicol hydrochloride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (±)-Vesamicol hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||14.79||50 with gentle warming|
Preparing Stock Solutions for (±)-Vesamicol hydrochloride
The following data is based on the product molecular weight 295.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.76 mL||33.8 mL||67.6 mL|
|2.5 mM||1.35 mL||6.76 mL||13.52 mL|
|5 mM||0.68 mL||3.38 mL||6.76 mL|
|25 mM||0.14 mL||0.68 mL||1.35 mL|
Product Datasheets for (±)-Vesamicol hydrochloride
References for (±)-Vesamicol hydrochloride
References are publications that support the biological activity of the product.
Efange et al (1997) N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J.Med.Chem. 40 3905 PMID: 9397171
Kobayashi et al (1997) Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res.Bull. 43 17 PMID: 9205789
Varoqui and Erickson (1996) Active transport of acetylcholine by the human vesicular acetylcholine transporter. J.Biol.Chem. 271 27229 PMID: 8910293
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Citations for (±)-Vesamicol hydrochloride
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Literature in this Area
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