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(±)-Cloprostenol sodium salt
Water-soluble prostaglandin F2α (PGF2α) analog; acts as a potent FP receptor agonist (EC50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 446.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.19 mL||55.94 mL||111.88 mL|
|1 mM||2.24 mL||11.19 mL||22.38 mL|
|2 mM||1.12 mL||5.59 mL||11.19 mL|
|10 mM||0.22 mL||1.12 mL||2.24 mL|
References are publications that support the biological activity of the product.
Dukes et al (1974) Potent luteolytic agents related to prostaglandin F2α. Nature 250 330 PMID: 4853720
Griffin et al (1998) Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization. J.Pharmacol.Exp.Ther. 286 411 PMID: 9655886
Serrero and Lepak (2002) Prostaglandin F2α receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochem.Biophys.Res.Comm. 233 200
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Keywords: (±)-Cloprostenol sodium salt, (±)-Cloprostenol sodium salt supplier, Water-soluble, PGF2alpha, potent, FP, receptor, agonists, Receptors, Prostaglandin, Prostanoid, 2295, Tocris Bioscience
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.