(±)-Cloprostenol sodium salt

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Cat.No. 2295 - (±)-Cloprostenol sodium salt | C22H28ClNaO6 | CAS No. 55028-72-3
Description: Water-soluble PGF2α analog and potent FP receptor agonist
Chemical Name: (5Z)-rel-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid monosodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)

Biological Activity

Water-soluble prostaglandin F2α (PGF2α) analog; acts as a potent FP receptor agonist (EC50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo.

Technical Data

M. Wt 446.9
Formula C22H28ClNaO6
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 55028-72-3
PubChem ID 17756794
InChI Key IFEJLMHZNQJGQU-KXXGZHCCSA-M
Smiles [Na+].O[C@@H](COC1=CC(Cl)=CC=C1)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.94 20

Preparing Stock Solutions

The following data is based on the product molecular weight 446.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.19 mL 55.94 mL 111.88 mL
1 mM 2.24 mL 11.19 mL 22.38 mL
2 mM 1.12 mL 5.59 mL 11.19 mL
10 mM 0.22 mL 1.12 mL 2.24 mL

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References

References are publications that support the biological activity of the product.

Dukes et al (1974) Potent luteolytic agents related to prostaglandin F. Nature 250 330 PMID: 4853720

Griffin et al (1998) Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization. J.Pharmacol.Exp.Ther. 286 411 PMID: 9655886

Serrero and Lepak (2002) Prostaglandin F receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochem.Biophys.Res.Comm. 233 200


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Keywords: (±)-Cloprostenol sodium salt, (±)-Cloprostenol sodium salt supplier, Water-soluble, PGF2alpha, potent, FP, receptor, agonists, Receptors, Prostaglandin, Prostanoid, 2295, Tocris Bioscience

Citations for (±)-Cloprostenol sodium salt

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