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DJ-V 159

Cat. No. 6645 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: GPRC6A agonist
Chemical Name: N1,N3-Bis(4-cyano-3-(trifluoromethyl)phenyl)isophthalamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DJ-V 159

DJ-V 159 is a GPRC6A agonist. Activates ERK and stimulates cAMP production in GPRC6A expressing HEK-293 cells. Stimulates insulin secretion from mouse β-cells in vitro. Reduces blood glucose levels in mice in vivo.

Technical Data for DJ-V 159

M. Wt 502.37
Formula C24H12F6N4O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 2253744-53-3
PubChem ID 137319717
InChI Key VEVNLJLJLVESLL-UHFFFAOYSA-N
Smiles O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)C2=CC(C(NC3=CC(C(F)(F)F)=C(C#N)C=C3)=O)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DJ-V 159

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.05 20 with gentle warming

Preparing Stock Solutions for DJ-V 159

The following data is based on the product molecular weight 502.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.95 mL 49.76 mL 99.53 mL
1 mM 1.99 mL 9.95 mL 19.91 mL
2 mM 1 mL 4.98 mL 9.95 mL
10 mM 0.2 mL 1 mL 1.99 mL

Molarity Calculator

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References for DJ-V 159

References are publications that support the biological activity of the product.

Pi et al (2018) Computationally identified novel agonists for GPRC6A. PLoS One 13 e0195980 PMID: 29684031

If you know of a relevant reference for DJ-V 159, please let us know.

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1 Citation for DJ-V 159

Citations are publications that use Tocris products. Selected citations for DJ-V 159 include:

Sheng et al (2023) Substance P aggravates ligature-induced periodontitis in mice. Front Immunol 14 1099017 PMID: 37122730

Do you know of a great paper that uses DJ-V 159 from Tocris? Please let us know.

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