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Partial α-adrenergic agonist. Partial D2 dopaminergic receptor agonist. Competitive 5-HT antagonist.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 679.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.47 mL||7.36 mL||14.71 mL|
|5 mM||0.29 mL||1.47 mL||2.94 mL|
|10 mM||0.15 mL||0.74 mL||1.47 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
References are publications that support the biological activity of the product.
de Boer et al (1991) Carotid vascular effects of ergot. and dihydroergot. in the pig: no exclusive mediation via 5-HT1-like receptors. Br.J.Pharmacol. 104 183 PMID: 1664762
Doggrell et al (1992) Further analysis of the inhibitory effects of dihydroergotamine, cyprohept. and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. J.Auton.Pharmacol. 12 223 PMID: 1512277
Lesage et al (1998) Agonistic properties of alniditan, sumatr. and dihydroergot. on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br.J.Pharmacol. 123 1655 PMID: 9605573
Villalon et al (1992) Effects of S9977 and dihydroergot. in an animal experimental model for migraine. Pharmacol.Res. 25 125 PMID: 1635891
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Citations for Dihydroergotamine mesylate
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.