Discontinued Product

DIBA (Cat. No. 0470) has been withdrawn from sale for commercial reasons.
Description: Muscarinic antagonist, M2 > M3
Chemical Name: 5-[4-(4-Diethylaminobutyl)-1-piperidinylacetyl]-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one
Literature (2)

Biological Activity for DIBA

Potent muscarinic antagonist, 13-fold selective for M2 over M3 receptors.

Technical Data for DIBA

M. Wt 462.63
Storage Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for DIBA

Certificate of Analysis is currently unavailable on-line.
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References for DIBA

References are publications that support the biological activity of the product.

Bolognesi et al (1998) Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. J.Med.Chem. 41 4150 PMID: 9767650

Cohen et al (1993) Synthesis and structure-activity relationship of some 5-[[[(dialkylamino)alkyl]-1-piperidinyl]acetyl]-10,11-dihydro-5H-benzo[b,e][1,4]diazepin-11-ones as M2 selective antimuscarinics. J.Med.Chem. 36 162 PMID: 8421282

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Keywords: DIBA, DIBA supplier, Non-selective, Muscarinics, 0470, Tocris Bioscience

Citations for DIBA

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Currently there are no citations for DIBA.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Learning & Memory Poster

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.