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A relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 334.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.99 mL||14.95 mL||29.9 mL|
|5 mM||0.6 mL||2.99 mL||5.98 mL|
|10 mM||0.3 mL||1.49 mL||2.99 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References are publications that support the biological activity of the product.
Teh and Sugden (1998) Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch.Pharmacol. 358 522 PMID: 9840420
Ting et al (1999) Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br.J.Pharmacol. 127 987 PMID: 10433507
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Keywords: DH 97, DH 97 supplier, MT2, receptor, antagonist, Receptors, Melatonin, DH97, (MT), 1218, Tocris Bioscience
2 Citations for DH 97
Citations are publications that use Tocris products. Selected citations for DH 97 include:
Sjöblom et al (2003) Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. BMC Neurosci 284 G1034 PMID: 12584110
Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179 PMID: 21091649
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