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Submit ReviewDextromethorphan hydrobromide
Description: NMDA antagonist
Chemical Name: (9α,13α,14α)-3-Methoxy-17-methylmorphinan hydrobromide
Purity: ≥99% (HPLC)
Biological Activity
Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.
Technical Data
| M. Wt | 352.31 |
| Formula | C18H25NO.HBr |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 125-69-9 |
| PubChem ID | 5464025 |
| InChI Key | MISZALMBODQYFT-URVXVIKDSA-N |
| Smiles | [H][C@@]12[C@@H]4CC(C=CC(OC)=C3)=C3[C@@](CCN4C)1CCCC2.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.09 | 40 |
Preparing Stock Solutions
The following data is based on the product molecular weight 352.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.4 mM | 7.1 mL | 35.48 mL | 70.96 mL |
| 2 mM | 1.42 mL | 7.1 mL | 14.19 mL |
| 4 mM | 0.71 mL | 3.55 mL | 7.1 mL |
| 20 mM | 0.14 mL | 0.71 mL | 1.42 mL |
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References
References are publications that support the biological activity of the product.
Choi et al (1987) Dextrorophan and levorp. selectively block N-MthD.-aspartate receptor-mediated neurotoxicity on corticol neurons. J.Pharmacol.Exp.Ther. 242 713 PMID: 3039122
Keller et al (2008) Dextromethorphan is protective against sensitized N-MthD.-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain. Eur.J.Neurosci. 27 874 PMID: 18279363
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Keywords: Dextromethorphan hydrobromide, Dextromethorphan hydrobromide supplier, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 6700-34-1, 3071, Tocris Bioscience
1 Citation for Dextromethorphan hydrobromide
Citations are publications that use Tocris products. Selected citations for Dextromethorphan hydrobromide include:
Ghoshooni et al (2011) Milled Stress Reduces Morphine-Induced Locomotion in F2 NMRI Mice. Pharmacol Res Perspect 10 347 PMID: 24250364
Do you know of a great paper that uses Dextromethorphan hydrobromide from Tocris? Please let us know.
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