[Des-octanoyl]-Ghrelin (rat)

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Cat.No. 2951 - [des-octanoyl]-Ghrelin (rat) | Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg | CAS No. 307950-60-3
Description: Major circulating form of ghrelin; devoid of activity at GHS receptor
Alternative Names: Des-acyl ghrelin (rat)
Datasheet
Citations (2)
Literature

Biological Activity

Non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release.

Technical Data

M. Wt 3188.63
Formula C139H231N45O41
Sequence GSSFLSPEHQKAQQRKESKKPPAKLQPR
Storage Desiccate at -20°C
CAS Number 307950-60-3
PubChem ID 90488789
InChI Key CMCPTGQGZXKKEH-MGXJLMSJSA-N
Smiles [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3188.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.31 mL 1.57 mL 3.14 mL
5 mM 0.06 mL 0.31 mL 0.63 mL
10 mM 0.03 mL 0.16 mL 0.31 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bedendi et al (2003) Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur.J.Pharmacol. 476 87 PMID: 12969753

Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor Endocrinology 145 234 PMID: 14551228

Cassoni et al (2004) Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur.J.Endocrinol. 150 173 PMID: 14763915


If you know of a relevant reference for [Des-octanoyl]-Ghrelin (rat), please let us know.

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Keywords: circulating ghrelin devoid activity GHS-R1a Receptors Growth Hormone Secretagogue Receptor 1a Ghrelin Des-acyl ghrelin (rat) Ghrelin Receptors

2 Citations for [Des-octanoyl]-Ghrelin (rat)

Citations are publications that use Tocris products. Selected citations for [Des-octanoyl]-Ghrelin (rat) include:

Engel et al (2015) Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition. Psychopharmacology (Berl) 232 4285 PMID: 26319159

Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. Br J Pharmacol 57 633 PMID: 21220707


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