[Des-octanoyl]-Ghrelin (human)

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Cat.No. 2260 - [Des-Octanoyl]-Ghrelin (human) | Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg | CAS No. 313951-59-6
Description: Major circulating form of ghrelin; devoid of activity at ghrelin receptor but is active in vivo
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

Non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. However, exerts negative inotropic effects in papillary muscle and displays cardioprotective activity. Inhibits cell proliferation in breast and prostate cancer cell lines. Promotes adipogenesis in vivo.

Technical Data

M. Wt 3244.51
Formula C141H235N47O41
Sequence GSSFLSPEHQRVQQRKESKKPPAKLQPR
Storage Desiccate at -20°C
CAS Number 313951-59-6
PubChem ID 46236457
InChI Key BGHSOEHUOOAYMY-JTZMCQEISA-N
Smiles [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Baldanzi et al (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J.Cell Biol. 159 1029 PMID: 12486113

Bedendi et al (2003) Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur.J.Pharmacol. 476 87 PMID: 12969753

Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a GH secretagogue receptor. Endocrinology 145 234 PMID: 14551228

Cassoni et al (2004) Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur.J.Endocrinol. 150 173 PMID: 14763915


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Keywords: [Des-Octanoyl]-Ghrelin (human), [Des-Octanoyl]-Ghrelin (human) supplier, circulating, ghrelin, devoid, activity, receptors, active, in, vivo, GHS-R1a, Growth, Hormone, Secretagog, 1a, Ghrelin, Receptors, 2260, Tocris Bioscience

1 Citation for [Des-octanoyl]-Ghrelin (human)

Citations are publications that use Tocris products. Selected citations for [Des-octanoyl]-Ghrelin (human) include:

Rodríguez et al (2009) Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. FASEB J 33 541 PMID: 19238155


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