des-Gln14-Ghrelin (rat)

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Cat.No. 1346 - des-Gln14-Ghrelin (rat) | Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg | CAS No. 293735-04-3
Description: Endogenous ghrelin receptor ligand
Datasheet
Citations
Reviews
Literature

Biological Activity

An endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. Potently induces Ca2+ release in cells expressing ghrelin receptors (EC50 = 2.4 nM) and stimulates GH release in vivo.

Licensing Information

This peptide is distributed under license from Dr. Kangawa

Technical Data

M. Wt 3186.7
Formula C142H237N43O40
Sequence GSSFLSPEHQKAQRKESKKPPAKLQPR

(Modifications: Ser-3 = Ser(n-octanoyl))

Storage Desiccate at -20°C
CAS Number 293735-04-3
PubChem ID 90479785
InChI Key GKDHXLGLEXRRSB-MVILVGDSSA-N
Smiles [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](COC(=O)CCCCCCC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hosoda et al (2000) Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J.Biol.Chem. 275 21995 PMID: 10801861


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Keywords: des-Gln14-Ghrelin (rat), des-Gln14-Ghrelin (rat) supplier, Endogenous, ghrelin, receptor, ligands, GHS-R1a, Receptors, Growth, Hormone, Secretagog, Receptor, 1a, Ghrelin, 1346, Tocris Bioscience

Citations for des-Gln14-Ghrelin (rat)

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Literature in this Area

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