des-Gln14-Ghrelin (rat)

Discontinued Product

des-Gln14-Ghrelin (rat) (Cat. No. 1346) has been withdrawn from sale for commercial reasons.
Description: Endogenous ghrelin receptor ligand
Literature (1)

Biological Activity for des-Gln14-Ghrelin (rat)

An endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. Potently induces Ca2+ release in cells expressing ghrelin receptors (EC50 = 2.4 nM) and stimulates GH release in vivo.

Licensing Information

This peptide is distributed under license from Dr. Kangawa

Technical Data for des-Gln14-Ghrelin (rat)

M. Wt 3186.7
Formula C142H237N43O40

(Modifications: Ser-3 = Ser(n-octanoyl))

Storage Desiccate at -20°C
CAS Number 293735-04-3
PubChem ID 90479785
Smiles [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](COC(=O)CCCCCCC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for des-Gln14-Ghrelin (rat)

Certificate of Analysis / Product Datasheet
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References for des-Gln14-Ghrelin (rat)

References are publications that support the biological activity of the product.

Hosoda et al (2000) Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the GH secretagogue receptor. J.Biol.Chem. 275 21995 PMID: 10801861

Keywords: des-Gln14-Ghrelin (rat), des-Gln14-Ghrelin (rat) supplier, Endogenous, ghrelin, receptor, ligands, GHS-R1a, Receptors, Growth, Hormone, Secretagog, Receptor, 1a, Ghrelin, 1346, Tocris Bioscience

Citations for des-Gln14-Ghrelin (rat)

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Currently there are no citations for des-Gln14-Ghrelin (rat).

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Literature in this Area

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Peptides Involved in Appetite Modulation Scientific Review

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.