des-Gln14-Ghrelin (rat)

Pricing Availability Delivery Time Qty
Cat.No. 1346 - des-Gln14-Ghrelin (rat) | Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg | CAS No. 293735-04-3
Description: Endogenous ghrelin receptor ligand
Datasheet
Citations
Literature

Biological Activity

An endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. Potently induces Ca2+ release in cells expressing ghrelin receptors (EC50 = 2.4 nM) and stimulates GH release in vivo.

Licensing Information

This peptide is distributed under license from Dr. Kangawa

Technical Data

M. Wt 3186.7
Formula C142H237N43O40
Sequence GSSFLSPEHQKAQRKESKKPPAKLQPR

(Modifications: Ser-3 = Ser(n-octanoyl))

Storage Desiccate at -20°C
CAS Number 293735-04-3
PubChem ID 90479785
InChI Key GKDHXLGLEXRRSB-MVILVGDSSA-N
Smiles [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](COC(=O)CCCCCCC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3186.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.31 mL 1.57 mL 3.14 mL
5 mM 0.06 mL 0.31 mL 0.63 mL
10 mM 0.03 mL 0.16 mL 0.31 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hosoda et al (2000) Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J.Biol.Chem. 275 21995 PMID: 10801861


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View Related Products by Target

Keywords: Endogenous ghrelin receptor ligands GHS-R1a Receptors Growth Hormone Secretagog Receptor 1a Ghrelin Receptors

Citations for des-Gln14-Ghrelin (rat)

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Literature in this Area

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Peptides Involved in Appetite Modulation Scientific Review

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Pathways for des-Gln14-Ghrelin (rat)

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