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Biological Activity for dCeMM2
dCeMM2 is a molecular glue degrader. Induces ubiquitination and degradation of cyclin K by eliciting an interaction of CDK12-cyclin K with a CRL4B ligase complex. dCeMM2 displays near-total degradation of protein at 2.5 μM within 2h. Cell-permeable.
Technical Data for dCeMM2
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for dCeMM2
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for dCeMM2
The following data is based on the product molecular weight 370.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.39 mL||26.97 mL||53.93 mL|
|2.5 mM||1.08 mL||5.39 mL||10.79 mL|
|5 mM||0.54 mL||2.7 mL||5.39 mL|
|25 mM||0.11 mL||0.54 mL||1.08 mL|
References for dCeMM2
References are publications that support the biological activity of the product.
Mayor-Ruiz et al (2020) Rational discovery of molecular glue degraders via scalable chemical profiling. Nat.Chem.Biol. 16 1199 PMID: 32747809
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Keywords: dCeMM2, dCeMM2 supplier, molecular, glue, degraders, degrades, cyclin, K, CDK12, CRL4B, ligase, DDB1, ubiquitination, proteasomal, degradation, Molecular, Glues, Transcriptional, CDKs, 7525, Tocris Bioscience
Citations for dCeMM2
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Literature in this Area
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Targeted Protein Degradation Research Product Guide
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
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