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dCeMM2 is a molecular glue degrader. Induces ubiquitination and degradation of cyclin K by eliciting an interaction of CDK12-cyclin K with a CRL4B ligase complex. dCeMM2 displays near-total degradation of protein at 2.5 μM within 2h. Cell-permeable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 370.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.39 mL||26.97 mL||53.93 mL|
|2.5 mM||1.08 mL||5.39 mL||10.79 mL|
|5 mM||0.54 mL||2.7 mL||5.39 mL|
|25 mM||0.11 mL||0.54 mL||1.08 mL|
References are publications that support the biological activity of the product.
Mayor-Ruiz et al (2020) Rational discovery of molecular glue degraders via scalable chemical profiling. Nat.Chem.Biol. 16 1199 PMID: 32747809
If you know of a relevant reference for dCeMM2, please let us know.
Keywords: dCeMM2, dCeMM2 supplier, molecular, glue, degraders, degrades, cyclin, K, CDK12, CRL4B, ligase, DDB1, ubiquitination, proteasomal, degradation, Molecular, Glues, Transcriptional, CDKs, 7525, Tocris Bioscience
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