dCeMM2

Pricing Availability   Qty
Description: Molecular glue Degrader; induces ubiquitination and degradation of cyclin K
Chemical Name: N-(5-Chloro-2-pyridinyl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for dCeMM2

dCeMM2 is a molecular glue degrader. Induces ubiquitination and degradation of cyclin K by eliciting an interaction of CDK12-cyclin K with a CRL4B ligase complex. dCeMM2 displays near-total degradation of protein at 2.5 μM within 2h. Cell-permeable.

Technical Data for dCeMM2

M. Wt 370.82
Formula C16H11ClN6OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 296771-07-8
PubChem ID 5286209
InChI Key VFWVTIHYVUKNGR-UHFFFAOYSA-N
Smiles O=C(NC1=NC=C(Cl)C=C1)CSC2=NN=C3C(NC4=C3C=CC=C4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for dCeMM2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.54 50

Preparing Stock Solutions for dCeMM2

The following data is based on the product molecular weight 370.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.39 mL 26.97 mL 53.93 mL
2.5 mM 1.08 mL 5.39 mL 10.79 mL
5 mM 0.54 mL 2.7 mL 5.39 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

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References for dCeMM2

References are publications that support the biological activity of the product.

Mayor-Ruiz et al (2020) Rational discovery of molecular glue degraders via scalable chemical profiling. Nat.Chem.Biol. 16 1199 PMID: 32747809


If you know of a relevant reference for dCeMM2, please let us know.

Keywords: dCeMM2, dCeMM2 supplier, molecular, glue, degraders, degrades, cyclin, K, CDK12, CRL4B, ligase, DDB1, ubiquitination, proteasomal, degradation, Molecular, Glues, Transcriptional, CDKs, 7525, Tocris Bioscience

Citations for dCeMM2

Citations are publications that use Tocris products.

Currently there are no citations for dCeMM2. Do you know of a great paper that uses dCeMM2 from Tocris? Please let us know.

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