DAU 5884 hydrochloride

Pricing Availability   Qty
Description: M3 receptor antagonist
Chemical Name: 8-Methyl-8-azabicyclo-3-endo[3.2.1]oct-3-yl-1,4-dihydro-2-oxo-3(2H)-quinazolinecarboxylic acid ester hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for DAU 5884 hydrochloride

DAU 5884 hydrochloride is a selective muscarinic M3 receptor antagonist. In bovine tracheal smooth muscle, inhibits methacholine-dependent effects on cell proliferation and muscle contractility.

Technical Data for DAU 5884 hydrochloride

M. Wt 351.83
Formula C17H21N3O3.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 131780-48-8
PubChem ID 16759154
Smiles Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)N1CC2=C(NC1=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DAU 5884 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 17.59 50
DMSO 35.18 100

Preparing Stock Solutions for DAU 5884 hydrochloride

The following data is based on the product molecular weight 351.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.42 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets for DAU 5884 hydrochloride

References for DAU 5884 hydrochloride

References are publications that support the biological activity of the product.

Doods et al (1993) Characterization of muscarinic receptors in guinea-pig uterus. Eur.J.Pharmacol. 250 223 PMID: 8112383

Roffel et al (1993) Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic M2-like receptors. Eur.J.Pharmacol. 250 267 PMID: 8112384

Gosens et al (2003) Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am.J.Respir.Cell Mol.Biol. 28 257 PMID: 12540494

Gosens et al (2004) Muscarinic M3 receptor-dependent regulation of airway smooth muscle contractile phenotype. Br.J.Pharmacol. 141 943 PMID: 14993104

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1 Citation for DAU 5884 hydrochloride

Citations are publications that use Tocris products. Selected citations for DAU 5884 hydrochloride include:

Zhu et al (2017) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun 8 1676 PMID: 29162816

Do you know of a great paper that uses DAU 5884 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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