Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDAU 5884 hydrochloride
Description: M3 receptor antagonist
Chemical Name: 8-Methyl-8-azabicyclo-3-endo[3.2.1]oct-3-yl-1,4-dihydro-2-oxo-3(2H)-quinazolinecarboxylic acid ester hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for DAU 5884 hydrochloride
DAU 5884 hydrochloride is a selective muscarinic M3 receptor antagonist. In bovine tracheal smooth muscle, inhibits methacholine-dependent effects on cell proliferation and muscle contractility.
Technical Data for DAU 5884 hydrochloride
| M. Wt | 351.83 |
| Formula | C17H21N3O3.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 131780-48-8 |
| PubChem ID | 16759154 |
| InChI Key | FDERDDSQHZRNGC-LIWIJTDLSA-N |
| Smiles | Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)N1CC2=C(NC1=O)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DAU 5884 hydrochloride
References for DAU 5884 hydrochloride
References are publications that support the biological activity of the product.
Doods et al (1993) Characterization of muscarinic receptors in guinea-pig uterus. Eur.J.Pharmacol. 250 223 PMID: 8112383
Roffel et al (1993) Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic M2-like receptors. Eur.J.Pharmacol. 250 267 PMID: 8112384
Gosens et al (2003) Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am.J.Respir.Cell Mol.Biol. 28 257 PMID: 12540494
Gosens et al (2004) Muscarinic M3 receptor-dependent regulation of airway smooth muscle contractile phenotype. Br.J.Pharmacol. 141 943 PMID: 14993104
View Related Products by Target
View Related Products by Product Action
Keywords: DAU 5884 hydrochloride, DAU 5884 hydrochloride supplier, M3, receptor, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, DAU5884, hydrochloride, 2096, Tocris Bioscience
1 Citation for DAU 5884 hydrochloride
Citations are publications that use Tocris products. Selected citations for DAU 5884 hydrochloride include:
Zhu et al (2017) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun 8 1676 PMID: 29162816
Reviews for DAU 5884 hydrochloride
There are currently no reviews for this product. Be the first to review DAU 5884 hydrochloride and earn rewards!
Have you used DAU 5884 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.