Discontinued Product

D9 (Cat. No. 5921) has been withdrawn from sale for commercial reasons.
Description: Potent thioredoxin reductase (TrxR) inhibitor
Chemical Name: (Diphenyl-2-thienylphosphine-κP)[2-(4-methoxyphenyl)ethynyl]gold
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for D9

D9 is a potent thioredoxin reductase (TrxR) inhibitor (EC50 = 2.8 nM, IC50 = 0.03 and 0.1 μM in MCF-7 cells and HT-29 cells, respectively). Highly stable in vivo; exhibits no significant ligand exchange with albumin. Inhibits tumor proliferation in vitro and in vivo by inducing cell death. Selectively kills cancer cells.

Technical Data for D9

M. Wt 596.43
Formula C25H20AuOPS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1527513-89-8
PubChem ID 127021039
Smiles [Au].COC1=CC=C(C=C1)C#C.S1C=CC=C1P(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for D9

References are publications that support the biological activity of the product.

Zhang et al (2014) Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase. J.Med.Chem. 57 8132 PMID: 25249032

Lin et al (2015) pH-sensitive polymeric nanoparticles with gold(I) compound payloads synergistically induce cancer cell death through modulation of autophagy. Mol.Pharm. 12 2869 PMID: 26101892

View Related Products by Target

View Related Products by Product Action

View all Thioredoxin Reductase Inhibitors

Keywords: D9, D9 supplier, Thioredoxin, reductase, TrxR, inhibitors, inhibits, anti-tumor, cancer, gold, Au, Reductases, 5921, Tocris Bioscience

1 Citation for D9

Citations are publications that use Tocris products. Selected citations for D9 include:

Wang et al (2019) Pyridine nucleotide regulation of hepatic endoplasmic reticulum calcium uptake. Physiol Rep 7 e14151 PMID: 31222964

Reviews for D9

There are currently no reviews for this product. Be the first to review D9 and earn rewards!

Have you used D9?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Autophagy Poster

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.