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Biological Activity for D9
D9 is a potent thioredoxin reductase (TrxR) inhibitor (EC50 = 2.8 nM, IC50 = 0.03 and 0.1 μM in MCF-7 cells and HT-29 cells, respectively). Highly stable in vivo; exhibits no significant ligand exchange with albumin. Inhibits tumor proliferation in vitro and in vivo by inducing cell death. Selectively kills cancer cells.
Technical Data for D9
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for D9
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for D9
The following data is based on the product molecular weight 596.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.68 mL||8.38 mL||16.77 mL|
|5 mM||0.34 mL||1.68 mL||3.35 mL|
|10 mM||0.17 mL||0.84 mL||1.68 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References for D9
References are publications that support the biological activity of the product.
Zhang et al (2014) Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase. J.Med.Chem. 57 8132 PMID: 25249032
Lin et al (2015) pH-sensitive polymeric nanoparticles with gold(I) compound payloads synergistically induce cancer cell death through modulation of autophagy. Mol.Pharm. 12 2869 PMID: 26101892
If you know of a relevant reference for D9, please let us know.
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Keywords: D9, D9 supplier, Thioredoxin, reductase, TrxR, inhibitors, inhibits, anti-tumor, cancer, gold, Au, Reductases, 5921, Tocris Bioscience
1 Citation for D9
Citations are publications that use Tocris products. Selected citations for D9 include:
Wang et al (2019) Pyridine nucleotide regulation of hepatic endoplasmic reticulum calcium uptake. Physiol Rep 7 e14151 PMID: 31222964
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Literature in this Area
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.