D9

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Cat.No. 5921 - D9 | C25H20AuOPS | CAS No. 1527513-89-8
Description: Potent thioredoxin reductase (TrxR) inhibitor
Chemical Name: (Diphenyl-2-thienylphosphine-κP)[2-(4-methoxyphenyl)ethynyl]gold
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent thioredoxin reductase (TrxR) inhibitor (EC50 = 2.8 nM, IC50 = 0.03 and 0.1 μM in MCF-7 cells and HT-29 cells, respectively). Highly stable in vivo; exhibits no significant ligand exchange with albumin. Inhibits tumor proliferation in vitro and in vivo by inducing cell death. Selectively kills cancer cells.

Technical Data

M. Wt 596.43
Formula C25H20AuOPS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1527513-89-8
PubChem ID 127021039
InChI Key DROLHVHTLXUINH-UHFFFAOYSA-O
Smiles [Au].COC1=CC=C(C=C1)C#C.S1C=CC=C1P(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 596.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.38 mL 16.77 mL
5 mM 0.34 mL 1.68 mL 3.35 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (2014) Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase. J.Med.Chem. 57 8132 PMID: 25249032

Lin et al (2015) pH-sensitive polymeric nanoparticles with gold(I) compound payloads synergistically induce cancer cell death through modulation of autophagy. Mol.Pharm. 12 2869 PMID: 26101892


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Keywords: D9, supplier, Thioredoxin, reductase, TrxR, inhibitors, inhibits, anti-tumor, cancer, gold, Au, TrxR, TrxR, Tocris Bioscience

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