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Cannabinoid receptor agonist (Ki values are 5.05 and 3.13 nM for CB1 and CB2 receptors respectively; EC50 values are 6, 0.4 and 8 nM at CB1, CB2 and GPR55 receptors respectively). Major psychoactive constituent of marijuana. Shown to inhibit lung cancer growth and metastasis in an in vivo mouse model.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
Pertwee (2008) The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. Br.J.Pharmacol. 153 199 PMID: 17828291
Preet et al (2008) Δ9-tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 27 339 PMID: 17621270
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