Antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.
(Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.50 mg/ml in water|
References are publications that support the biological activity of the product.
Pinilla et al (2003) Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 77 83 PMID: 12624529
Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565 PMID: 9574823
Traebert et al (2002) Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J.Neuroendocrinol. 14 580 PMID: 12121496
If you know of a relevant reference for [D-Lys3]-GHRP-6, please let us know.
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Keywords: [D-Lys3]-GHRP-6, [D-Lys3]-GHRP-6 supplier, Ghrelin, receptors, antagonists, GHS-R1a, Growth, Hormone, Secretagog, 1a, Receptors, 1922, Tocris Bioscience
5 Citations for [D-Lys3]-GHRP-6
Citations are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:
Kamei et al (2017) Rikkunshito prevents paclitaxel-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice. PLoS One 12 e0171819 PMID: 28182729
Gomez and (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res 38 2436 PMID: 25257292
Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. PLoS Comput Biol 57 633 PMID: 21220707
Hashiguchi (2017) Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS One 12 e0184261 PMID: 28877214
Song et al (2013) Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion. PLoS One 8 e65422 PMID: 23762368
Do you know of a great paper that uses [D-Lys3]-GHRP-6 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.