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Description: Ghrelin receptor antagonist
Purity: ≥95% (HPLC)
Citations (6)
Literature (1)

Biological Activity for [D-Lys3]-GHRP-6

[D-Lys3]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.

Technical Data for [D-Lys3]-GHRP-6

M. Wt 930.12
Formula C49H63N13O6
Sequence HWKWFK

(Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 136054-22-3
PubChem ID 5311279
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for [D-Lys3]-GHRP-6

Solubility Soluble to 0.50 mg/ml in water

Product Datasheets for [D-Lys3]-GHRP-6

Certificate of Analysis / Product Datasheet
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References for [D-Lys3]-GHRP-6

References are publications that support the biological activity of the product.

Pinilla et al (2003) Role of ghrelin in the control of GH secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 77 83 PMID: 12624529

Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565 PMID: 9574823

Traebert et al (2002) Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J.Neuroendocrinol. 14 580 PMID: 12121496

If you know of a relevant reference for [D-Lys3]-GHRP-6, please let us know.

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View all Ghrelin Receptor Antagonists

Keywords: [D-Lys3]-GHRP-6, [D-Lys3]-GHRP-6 supplier, Ghrelin, receptors, antagonists, GHS-R1a, Growth, Hormone, Secretagog, 1a, Receptors, 1922, Tocris Bioscience

6 Citations for [D-Lys3]-GHRP-6

Citations are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:

Kamei et al (2017) Rikkunshito prevents PacT.-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice. PLoS One 12 e0171819 PMID: 28182729

Song et al (2013) Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion. PLoS One 8 e65422 PMID: 23762368

Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. PLoS Comput Biol 57 633 PMID: 21220707

Murtuza and Isokawa (2018) Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus. J Neurochem 144 58 PMID: 29063591

Do you know of a great paper that uses [D-Lys3]-GHRP-6 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.