Antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.
(Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.50 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 930.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.08 mL||5.38 mL||10.75 mL|
|5 mM||0.22 mL||1.08 mL||2.15 mL|
|10 mM||0.11 mL||0.54 mL||1.08 mL|
|50 mM||0.02 mL||0.11 mL||0.22 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Pinilla et al (2003) Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 77 83 PMID: 12624529
Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565 PMID: 9574823
Traebert et al (2002) Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J.Neuroendocrinol. 14 580 PMID: 12121496
If you know of a relevant reference for [D-Lys3]-GHRP-6, please let us know.
View Related Products by Product Action
Keywords: [D-Lys3]-GHRP-6, supplier, Ghrelin, receptors, antagonists, GHS-R1a, Growth, Hormone, Secretagog, 1a, Ghrelin, Receptors, Ghrelin, Receptors, Tocris Bioscience
2 Citations for [D-Lys3]-GHRP-6
Citations are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:
Gomez and (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res 38 2436 PMID: 25257292
Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. PLoS Comput Biol 57 633 PMID: 21220707
Do you know of a great paper that uses [D-Lys3]-GHRP-6 from Tocris? If so please let us know.
Literature in this Area
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.