Potent and competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 250.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4 mL||19.98 mL||39.97 mL|
|5 mM||0.8 mL||4 mL||7.99 mL|
|10 mM||0.4 mL||2 mL||4 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Lowe et al (1990) D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci.Lett. 113 315 PMID: 2166255
Potschka et al (1999) Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats. Eur.J.Pharmacol. 374 175 PMID: 10422758
Aebischer et al (1989) Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene). Helv.Chim.Acta 72 1043 PMID:
If you know of a relevant reference for D-CPP-ene, please let us know.
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Keywords: Potent competitive NMDA antagonists Glutamate Receptors N-Methyl-D-Aspartate iGlur Ionotropic SDZEAA494 Midafotel SDZ EAA 494 NMDA Receptors
1 Citation for D-CPP-ene
Citations are publications that use Tocris products. Selected citations for D-CPP-ene include:
Campos and Ritter (2015) NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation. Oncogene 308 R1 PMID: 25394828
Do you know of a great paper that uses D-CPP-ene from Tocris? If so please let us know.
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