D-CPP-ene

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Cat.No. 1265 - D-CPP-ene | C8H15N2O5P | CAS No. 117414-74-1
Description: Potent, competitive NMDA antagonist
Alternative Names: Midafotel, SDZ EAA 494
Chemical Name: D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid
Datasheet
Citations (1)
Literature

Biological Activity

Potent and competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.

Technical Data

M. Wt 250.19
Formula C8H15N2O5P
Storage Desiccate at RT
CAS Number 117414-74-1
PubChem ID 6435801
InChI Key VZXMZMJSGLFKQI-ABVWVHJUSA-N
Smiles O=P(/C=C/CN1C[C@H]([C@](O)=O)NCC1)(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 250.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4 mL 19.98 mL 39.97 mL
5 mM 0.8 mL 4 mL 7.99 mL
10 mM 0.4 mL 2 mL 4 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lowe et al (1990) D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci.Lett. 113 315 PMID: 2166255

Potschka et al (1999) Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats. Eur.J.Pharmacol. 374 175 PMID: 10422758

Aebischer et al (1989) Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene). Helv.Chim.Acta 72 1043 PMID:


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Keywords: D-CPP-ene, supplier, Potent, competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, SDZEAA494, Midafotel, SDZ, EAA, 494, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

1 Citation for D-CPP-ene

Citations are publications that use Tocris products. Selected citations for D-CPP-ene include:

Campos and Ritter (2015) NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation. Oncogene 308 R1 PMID: 25394828


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Pathways for D-CPP-ene

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