Endogenous NMDA receptor agonist with similar activity to the L-isomer. Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.
L-isomer also available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in 1eq. NaOH|
Preparing Stock Solutions
The following data is based on the product molecular weight 133.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||7.51 mL||37.57 mL||75.13 mL|
|5 mM||1.5 mL||7.51 mL||15.03 mL|
|10 mM||0.75 mL||3.76 mL||7.51 mL|
|50 mM||0.15 mL||0.75 mL||1.5 mL|
References are publications that support the products' biological activity.
Hashimoto et al (1997) Free D-aspartate and D-serine in the mammalian brain and periphery. Prog.Neurobiol. 53 325 PMID: 9247969
Ishio et al (1998) D-Aspartate modulates melatonin synthesis in rat pinealocytes. Neurosci.Lett. 249 143 PMID: 9682837
Olverman et al (1988) Structure/activity relations of NMDA receptor ligands as studied by their inhibition of 3H-D-AP5 binding in rat brain membranes. Neuroscience 26 17 PMID: 2901691
If you know of a relevant reference for D-Aspartic acid, please let us know.
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Keywords: D-Aspartic acid, supplier, NMDA, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
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