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Cat.No. 3999 - Cyclofenil | C23H24O4 | CAS No. 2624-43-3
Description: Selective estrogen receptor modulator (SERM)
Chemical Name: 4,4'-(Cyclohexylidenemethylene)bisphenol 1,1'-diacetate
Purity: ≥99% (HPLC)

Biological Activity

Non-steroidal selective estrogen receptor modulator (SERM). Displays higher affinity for estrogen receptor β (ERβ) than for ERα.

Technical Data

M. Wt 364.43
Formula C23H24O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 2624-43-3
PubChem ID 2898
Smiles CC(OC(C=C3)=CC=C3/C(C2=CC=C(OC(C)=O)C=C2)=C1/CCCCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.64 10
ethanol 1.82 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 364.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Kieser et al (2010) Characterization of the pharmacore properties of novel selective estrogen receptor downregulators (SERDs). J.Med.Chem. 53 3320 PMID: 20334372

Seo et al (2006) Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential PET agents for imaging estrogen receptors in breast cancer. J.Med.Chem. 49 2496 PMID: 16610793

If you know of a relevant reference for Cyclofenil, please let us know.

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View all Estrogen and Related Receptor Modulators

Keywords: Non-steroidal selective estrogen receptors modulators SERM ERα ERβ Estrogen and Related Receptors

Citations for Cyclofenil

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
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Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
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  • Retinoid X Receptors
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Pathways for Cyclofenil


Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.


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