Cyclofenil

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Cat.No. 3999 - Cyclofenil | C23H24O4 | CAS No. 2624-43-3
Description: Selective estrogen receptor modulator (SERM)
Chemical Name: 4,4'-(Cyclohexylidenemethylene)bisphenol 1,1'-diacetate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity

Non-steroidal selective estrogen receptor modulator (SERM). Displays higher affinity for estrogen receptor β (ERβ) than for ERα.

Technical Data

M. Wt 364.43
Formula C23H24O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 2624-43-3
PubChem ID 2898
InChI Key GVOUFPWUYJWQSK-UHFFFAOYSA-N
Smiles CC(OC(C=C3)=CC=C3/C(C2=CC=C(OC(C)=O)C=C2)=C1/CCCCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.64 10

Preparing Stock Solutions

The following data is based on the product molecular weight 364.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.44 mL 137.2 mL 274.4 mL
0.5 mM 5.49 mL 27.44 mL 54.88 mL
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Kieser et al (2010) Characterization of the pharmacore properties of novel selective estrogen receptor downregulators (SERDs). J.Med.Chem. 53 3320 PMID: 20334372

Seo et al (2006) Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential PET agents for imaging estrogen receptors in breast cancer. J.Med.Chem. 49 2496 PMID: 16610793


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Keywords: Cyclofenil, Cyclofenil supplier, Non-steroidal, selective, estrogen, receptors, modulators, SERM, ERα, ERβ, Estrogen, and, Related, Receptors, 3999, Tocris Bioscience

Citations for Cyclofenil

Citations are publications that use Tocris products.

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Literature in this Area

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Cancer

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Nuclear Receptors

Nuclear Receptors Product Listing

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Pathways for Cyclofenil

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.