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Description: Selective mitochondrial citrate transporter (SLC25A1) inhibitor
Chemical Name: 2-[[(4-Chloro-3-nitrophenyl)sulfonyl]amino]benzoic acid
Purity: ≥98% (HPLC)

Biological Activity for CTPI 2

CTPI 2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor with a KD of 3.5 μM. CTPI 2 inhibits the proliferation of H1299 cells in a SLC25A1-dependent manner. It also re-sensitizes T1, T2, and T4 cells to Cisplatin (Cat. No. 2251). CTPI 2 inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC). In high-fat diet fed mice CTPI 2 regulates glycolysis, prevents steatohepatitis and normalizes glucose tolerance and insulin sensitivity. CTPI 2 influences the inflammatory pathway by inhibiting IL-6 and TNFα production and M1 macrophage polarization.

Technical Data for CTPI 2

M. Wt 356.74
Formula C13H9ClN2O6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 68003-38-3
Smiles O=C(O)C=1C=CC=CC1NS(=O)(=O)C2=CC=C(Cl)C(=C2)N(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CTPI 2

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.67 100
ethanol 7.13 20

Preparing Stock Solutions for CTPI 2

The following data is based on the product molecular weight 356.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 14.02 mL 28.03 mL
5 mM 0.56 mL 2.8 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References for CTPI 2

References are publications that support the biological activity of the product.

Tan et al (2020) Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 27 2143 PMID: 31959914

Fernandez et al (2018) The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ. 25 1239 PMID: 29651165

Batchuluun et al (2022) Lipogenesis inhibitors: therapeutic opportunities and challenges. Nat.Rev.Drug Discov. 21 283 PMID: 35031766

If you know of a relevant reference for CTPI 2, please let us know.

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Keywords: CTPI 2, CTPI 2 supplier, CTPI-2, selective, inhibitor, inhibits, mitochondrial, citrate, transporter, SLC25A1, steatohepatitis, glycolysis, carrier, Other, Ion, Pumps/Transporters, 7794, Tocris Bioscience

Citations for CTPI 2

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