Discontinued ProductUnfortunately Cortistatin-8 (Cat. No. 3033) has been withdrawn from sale for commercial reasons.
Synthetic cortistatin analog that lacks the ability to bind somatostatin receptors but retains ghrelin receptor binding. Acts as a ghrelin receptor antagonist; counteracts the response of ghrelin on gastric acid secretion.
(Modifications: Trp-4 = D-Trp, Disulfide bridge between 2 - 7, Lys-8 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1009.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.99 mL||4.95 mL||9.91 mL|
|5 mM||0.2 mL||0.99 mL||1.98 mL|
|10 mM||0.1 mL||0.5 mL||0.99 mL|
|50 mM||0.02 mL||0.1 mL||0.2 mL|
References are publications that support the products' biological activity.
Luque et al (2006) Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes. J.Mol.Endocrinol. 36 547 PMID: 16720722
Sibilia et al (2006) Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat. J.Neuroendocrinol. 18 122 PMID: 16420281
Prodam et al (2008) Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides 42 89 PMID: 18061663
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Keywords: Cortistatin-8, supplier, Ghrelin, receptor, antagonists, GHS-R1a, Receptors, Growth, Hormone, Secretagogue, 1a, CST8, CST-8, Ghrelin, Receptors, Ghrelin, Receptors, Tocris Bioscience
Citations for Cortistatin-8
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Currently there are no citations for Cortistatin-8.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.