Cortistatin-8

Discontinued Product

Cortistatin-8 (Cat. No. 3033) has been withdrawn from sale for commercial reasons.
Cat.No. 3033 - Cortistatin-8 | Pro-Cys-Phe-D-Trp-Lys-Thr-Cys-Lys-NH2 | CAS No. 485803-62-1
Description: Ghrelin receptor antagonist
Alternative Names: CST-8
Datasheet
Citations
Reviews
Literature

Biological Activity

Synthetic cortistatin analog that lacks the ability to bind somatostatin receptors but retains ghrelin receptor binding. Acts as a ghrelin receptor antagonist; counteracts the response of ghrelin on gastric acid secretion.

Technical Data

M. Wt 1009.25
Formula C47H68N12O9S2
Sequence PCFWKTCK

(Modifications: Trp-4 = D-Trp, Disulfide bridge between 2 - 7, Lys-8 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 485803-62-1
PubChem ID 9854662
InChI Key UHALUVNIZLPZSZ-BPBAYLLVSA-N
Smiles [H]N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Luque et al (2006) Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes. J.Mol.Endocrinol. 36 547 PMID: 16720722

Sibilia et al (2006) Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat. J.Neuroendocrinol. 18 122 PMID: 16420281

Prodam et al (2008) Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides 42 89 PMID: 18061663

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Keywords: Cortistatin-8, Cortistatin-8 supplier, Ghrelin, receptor, antagonists, GHS-R1a, Receptors, Growth, Hormone, Secretagogue, 1a, CST8, CST-8, 3033, Tocris Bioscience

Citations for Cortistatin-8

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Literature in this Area

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