Non-competitive NMDA receptor antagonist (IC50 = 0.4 μM). Inhibits Ca2+ influx and glutamate-induced toxicity in central nervous system neurons. Exhibits age-dependent physiological effects; induces a sleep-like state in young mice and hyperactivity in older mice.
Sold under license from University of Utah
(Modifications: X = Gla, Ala-21 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 2683.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.37 mL||1.86 mL||3.73 mL|
|5 mM||0.07 mL||0.37 mL||0.75 mL|
|10 mM||0.04 mL||0.19 mL||0.37 mL|
|50 mM||0.01 mL||0.04 mL||0.07 mL|
References are publications that support the products' biological activity.
Haack et al (1990) Conantokin-T. J.Biol.Chem. 265 6025 PMID: 2180939
Klein et al (1999) Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons. Neuropharmacology 38 1819 PMID: 10608277
Warder et al (2001) Amino acid determinants for NMDA receptor inhibition by conantokin-T. J.Neurochem. 77 812 PMID: 11331410
If you know of a relevant reference for Conantokin-T, please let us know.
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Keywords: Conantokin-T, supplier, Non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, venoms, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
Citations for Conantokin-T
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