Conantokin-T

Pricing Availability Delivery Time Qty
Cat.No. 3122 - Conantokin-T | Gly-Glu-Gla-Gla-Tyr-Gln-Lys-Met-Leu-Gla-Asn-Leu-Arg-Gla-Ala-Glu-Val-Lys-Lys-Asn-Ala-NH2 | CAS No. 127476-26-0
Description: Non-competitive NMDA receptor antagonist
Datasheet
Citations
Literature

Biological Activity

Non-competitive NMDA receptor antagonist (IC50 = 0.4 μM). Inhibits Ca2+ influx and glutamate-induced toxicity in central nervous system neurons. Exhibits age-dependent physiological effects; induces a sleep-like state in young mice and hyperactivity in older mice.

Licensing Information

Sold under license from University of Utah

Technical Data

M. Wt 2683.8
Formula C110H175N31O45S
Sequence GEXXYQKMLXNLRXAEVKKNA

(Modifications: X = Gla, Ala-21 = C-terminal amide)

Storage Store at -20°C
CAS Number 127476-26-0
PubChem ID 16143008
InChI Key UFVIUSQQHPISRQ-HNJXWIPGSA-N
Smiles [H]NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 2683.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.37 mL 1.86 mL 3.73 mL
5 mM 0.07 mL 0.37 mL 0.75 mL
10 mM 0.04 mL 0.19 mL 0.37 mL
50 mM 0.01 mL 0.04 mL 0.07 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Haack et al (1990) Conantokin-T. J.Biol.Chem. 265 6025 PMID: 2180939

Klein et al (1999) Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons. Neuropharmacology 38 1819 PMID: 10608277

Warder et al (2001) Amino acid determinants for NMDA receptor inhibition by conantokin-T. J.Neurochem. 77 812 PMID: 11331410


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Keywords: Conantokin-T, supplier, Non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, venoms, NMDA, Receptors, Tocris Bioscience

Citations for Conantokin-T

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