Potent, non-competitive NMDA receptor antagonist (IC50 = 93 nM) that has been suggested to have NR2 subunit selectivity. Inhibits inward currents evoked by NMDA in central nervous system neurons (IC50 = 350 nM) and exhibits broad anticonvulsant and antiparkinsonian activity in vivo at doses devoid of behavioral toxicity.
Sold under license from University of Utah
(Modifications: X = Gla, Disulfide bridge between 21 - 25)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 3098.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.32 mL||1.61 mL||3.23 mL|
|5 mM||0.06 mL||0.32 mL||0.65 mL|
|10 mM||0.03 mL||0.16 mL||0.32 mL|
|50 mM||0.01 mL||0.03 mL||0.06 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Blandl et al (2000) Structure-function relationships of the NMDA-receptor antagonist peptide, conantokin-R. FEBS Lett. 470 139 PMID: 10734223
Klein et al (2001) The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors. J.Biol.Chem. 276 26860 PMID: 11335724
White et al (2000) In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J.Pharmacol.Expr.Ther. 292 425 PMID:
If you know of a relevant reference for Conantokin-R, please let us know.
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Keywords: Potent non-competitive NMDA receptor antagonists Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic venoms NMDA Receptors
Citations for Conantokin-R
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