Conantokin G

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Cat.No. 4136 - Conantokin G | Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2 | CAS No. 93438-65-4
Description: GluN2B-selective NMDA antagonist
Literature (11)

Biological Activity for Conantokin G

Conantokin G is a GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally NR2A), subunits (IC50 ~300 nM). Exhibits neuroprotective properties in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for Conantokin G

M. Wt 2264.21
Formula C88H138N26O44

(Modifications: X = Gla, Asn-17 = C-terminal amide)

Storage Store at -20°C
CAS Number 93438-65-4
PubChem ID 16132376

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Conantokin G

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Conantokin G

Certificate of Analysis / Product Datasheet
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References for Conantokin G

References are publications that support the biological activity of the product.

Donevan and McCabe (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol.Pharmacol. 58 614 PMID: 10953056

Bush et al (2000) Selective antagonism of nigral neuropeptide responses to metha. by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 387 55 PMID: 10633160

Williams et al (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp.Ther. 294 378 PMID: 10871336

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Keywords: Conantokin G, Conantokin G supplier, neuroprotective, NMDA, receptors, antagonists, NR2B, selective, venoms, GluN2B, Receptors, 4136, Tocris Bioscience

Citations for Conantokin G

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