Clofibrate

Pricing Availability Delivery Time Qty
Cat.No. 0824 - Clofibrate | C12H15ClO3 | CAS No. 637-07-0
Description: PPAR agonist
Chemical Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropionate
Datasheet
Citations
Literature

Biological Activity

PPAR agonist (EC50 values are 50, 500 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Antihyperlipoproteinemic.

Technical Data

M. Wt 242.7017
Formula C12H15ClO3
Storage Store at RT
CAS Number 637-07-0
PubChem ID 2796
InChI Key KNHUKKLJHYUCFP-UHFFFAOYSA-N
Smiles ClC1=CC=C(OC(C)(C)C(OCC)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.27 100

Preparing Stock Solutions

The following data is based on the product molecular weight 242.7017. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.12 mL 20.6 mL 41.2 mL
5 mM 0.82 mL 4.12 mL 8.24 mL
10 mM 0.41 mL 2.06 mL 4.12 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bishop-Bailey (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 129 823 PMID: 10696077

Shepherd (1993) Mechanism of action of fibrates. Postgrad.Med.J. 69 S34 PMID: 8497455

Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680

Merck Index 12 2437 PMID:


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Keywords: Clofibrate, supplier, PPAR, agonists, Non-Selective, Peroxisome, Proliferator-activating, Receptors, Non-selective, PPAR, Non-selective, PPAR, Tocris Bioscience

Citations for Clofibrate

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Literature in this Area

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Pathways for Clofibrate

Protocols

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