Clofibrate

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Description: PPAR agonist
Chemical Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropionate
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Biological Activity for Clofibrate

Clofibrate is a PPAR agonist (EC50 values are 50, 500 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Antihyperlipoproteinemic.

Technical Data for Clofibrate

M. Wt 242.7017
Formula C12H15ClO3
Storage Store at RT
CAS Number 637-07-0
PubChem ID 2796
InChI Key KNHUKKLJHYUCFP-UHFFFAOYSA-N
Smiles ClC1=CC=C(OC(C)(C)C(OCC)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Clofibrate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.27 100

Preparing Stock Solutions for Clofibrate

The following data is based on the product molecular weight 242.7017. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.12 mL 20.6 mL 41.2 mL
5 mM 0.82 mL 4.12 mL 8.24 mL
10 mM 0.41 mL 2.06 mL 4.12 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Clofibrate

References are publications that support the biological activity of the product.

Bishop-Bailey (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 129 823 PMID: 10696077

Shepherd (1993) Mechanism of action of fibrates. Postgrad.Med.J. 69 S34 PMID: 8497455

Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680

Merck Index 12 2437


If you know of a relevant reference for Clofibrate, please let us know.

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Keywords: Clofibrate, Clofibrate supplier, PPAR, agonists, Non-Selective, Peroxisome, Proliferator-activating, Receptors, Non-selective, 0824, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Clofibrate, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Citations for Clofibrate

Citations are publications that use Tocris products.

Currently there are no citations for Clofibrate. Do you know of a great paper that uses Clofibrate from Tocris? Please let us know.

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