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Biological Activity for Clofibrate
Clofibrate is a PPAR agonist (EC50 values are 50, 500 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Antihyperlipoproteinemic.
Technical Data for Clofibrate
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Clofibrate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Clofibrate
The following data is based on the product molecular weight 242.7017. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.12 mL||20.6 mL||41.2 mL|
|5 mM||0.82 mL||4.12 mL||8.24 mL|
|10 mM||0.41 mL||2.06 mL||4.12 mL|
|50 mM||0.08 mL||0.41 mL||0.82 mL|
References for Clofibrate
References are publications that support the biological activity of the product.
Bishop-Bailey (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 129 823 PMID: 10696077
Shepherd (1993) Mechanism of action of fibrates. Postgrad.Med.J. 69 S34 PMID: 8497455
Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680
Merck Index 12 2437
If you know of a relevant reference for Clofibrate, please let us know.
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Keywords: Clofibrate, Clofibrate supplier, PPAR, agonists, Non-Selective, Peroxisome, Proliferator-activating, Receptors, Non-selective, 0824, Tocris Bioscience
Citations for Clofibrate
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Literature in this Area
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