Potent, selective CysLT1 (LTD4) leukotriene receptor antagonist (IC50 = 6.4 nM). Inhibits LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 412.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.42 mL||12.12 mL||24.24 mL|
|5 mM||0.48 mL||2.42 mL||4.85 mL|
|10 mM||0.24 mL||1.21 mL||2.42 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
O'Donnell (1991) Ro 24-5913: a potent, specific, orally active LTD4 antagonist. Ann.N.Y.Acad.Sci. 629 413 PMID: 1659286
O'Donnell et al (1991) Pharmacologic actions of Ro 24-5913, a novel antagonist of leukotriene D4. J.Pharmacol.Exp.Ther. 259 751 PMID: 1658310
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Keywords: Cinalukast, supplier, Potent, selective, CysLT1, LTD4, antagonists, orally, active, Receptors, LTE4, leukotrienes, eicosanoids, Ro245913, Ro, 24-5913, Leukotriene, and, Related, Receptors, Tocris Bioscience
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