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Cat.No. 2025 - Cinalukast | C23H28N2O3S | CAS No. 128312-51-6
Description: Potent, selective CysLT1 (LTD4) antagonist; orally active
Alternative Names: Ro 24-5913
Chemical Name: 4-[[3-[(1E)-2-(4-Cyclobutyl-2-thiazolyl)ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid
Purity: ≥98% (HPLC)

Biological Activity

Potent, selective CysLT1 (LTD4) leukotriene receptor antagonist (IC50 = 6.4 nM). Inhibits LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.

Compound Libraries

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Technical Data

M. Wt 412.55
Formula C23H28N2O3S
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 128312-51-6
PubChem ID 6436135
Smiles CCC(CC)(CC(=O)NC1=CC(\C=C\C2=NC(=CS2)C2CCC2)=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.26 100
ethanol 4.13 10

Preparing Stock Solutions

The following data is based on the product molecular weight 412.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References are publications that support the products' biological activity.

O'Donnell (1991) Ro 24-5913: a potent, specific, orally active LTD4 antagonist. Ann.N.Y.Acad.Sci. 629 413 PMID: 1659286

O'Donnell et al (1991) Pharmacologic actions of Ro 24-5913, a novel antagonist of leukotriene D4. J.Pharmacol.Exp.Ther. 259 751 PMID: 1658310

If you know of a relevant reference for Cinalukast, please let us know.

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View all Leukotriene and Related Receptor Antagonists

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