CIMBA hydrochloride

Pricing Availability   Qty
Description: Potent and selective G protein-coupled estrogen receptor (GPER) antagonist
Chemical Name: N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-4-methoxybenzenemethanamine hydrochloride
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for CIMBA hydrochloride

CIMBA hydrochloride is a potent G protein-coupled estrogen receptor (GPER) antagonist (IC50 = 75 nM). In vivo, it prevents the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER pathway in female ovariectomized mice.

Licensing Information

Sold under licence from Saint Louis University.

Technical Data for CIMBA hydrochloride

M. Wt 373.97
Formula C23H31NO.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CIMBA hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.4 100
ethanol 37.4 100

Preparing Stock Solutions for CIMBA hydrochloride

The following data is based on the product molecular weight 373.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.37 mL 26.74 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for CIMBA hydrochloride

References for CIMBA hydrochloride

References are publications that support the biological activity of the product.

DeLeon et al (2020) A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. J.Lipid Res. 61 767 PMID: 32127396

If you know of a relevant reference for CIMBA hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Estrogen (GPER) Receptor Antagonists

Keywords: CIMBA hydrochloride, CIMBA hydrochloride supplier, CIMBA, HCl, potent, selective, GPER, antagonists, antagonism, estrogen, oestrogen, receptors, in, vivo, Estrogen, (GPER), Receptors, 7812, Tocris Bioscience

Citations for CIMBA hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for CIMBA hydrochloride. Do you know of a great paper that uses CIMBA hydrochloride from Tocris? Please let us know.

Reviews for CIMBA hydrochloride

There are currently no reviews for this product. Be the first to review CIMBA hydrochloride and earn rewards!

Have you used CIMBA hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for CIMBA hydrochloride

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.