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CIMBA hydrochloride is a potent G protein-coupled estrogen receptor (GPER) antagonist (IC50 = 75 nM). In vivo, it prevents the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER pathway in female ovariectomized mice.
Sold under licence from Saint Louis University.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 373.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.67 mL||13.37 mL||26.74 mL|
|5 mM||0.53 mL||2.67 mL||5.35 mL|
|10 mM||0.27 mL||1.34 mL||2.67 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
References are publications that support the biological activity of the product.
DeLeon et al (2020) A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. J.Lipid Res. 61 767 PMID: 32127396
If you know of a relevant reference for CIMBA hydrochloride, please let us know.
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