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Biological Activity for CIMBA hydrochloride
CIMBA hydrochloride is a potent G protein-coupled estrogen receptor (GPER) antagonist (IC50 = 75 nM). In vivo, it prevents the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER pathway in female ovariectomized mice.
Sold under licence from Saint Louis University.
Technical Data for CIMBA hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CIMBA hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CIMBA hydrochloride
The following data is based on the product molecular weight 373.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.67 mL||13.37 mL||26.74 mL|
|5 mM||0.53 mL||2.67 mL||5.35 mL|
|10 mM||0.27 mL||1.34 mL||2.67 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
Product Datasheets for CIMBA hydrochloride
References for CIMBA hydrochloride
References are publications that support the biological activity of the product.
DeLeon et al (2020) A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. J.Lipid Res. 61 767 PMID: 32127396
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Citations for CIMBA hydrochloride
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