CID 5951923

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Cat.No. 4446 - CID 5951923 | C16H18N2O7S | CAS No. 749872-43-3
Description: Krüppel-like factor 5 (KLF5) inhibitor
Chemical Name: 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl (E)-3-(3-nitrophenyl)prop-2-enoate
Purity: ≥97% (HPLC)

Biological Activity for CID 5951923

CID 5951923 is an inhibitor of Krüppel-like factor 5 (KLF5) transcription factor (IC50 = 2.3 μM). Selectively active against colon cancer cells in a panel of 60 different cancer cell lines.

Technical Data for CID 5951923

M. Wt 382.39
Formula C16H18N2O7S
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 749872-43-3
PubChem ID 5951923
Smiles O=C(OCC(N(C)C2CS(CC2)(=O)=O)=O)/C=C/C1=CC([N+]([O-])=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CID 5951923

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.24 100

Preparing Stock Solutions for CID 5951923

The following data is based on the product molecular weight 382.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.08 mL 26.15 mL
5 mM 0.52 mL 2.62 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References for CID 5951923

References are publications that support the biological activity of the product.

Bialkowska et al (2011) Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol.Cancer Ther. 10 2043 PMID: 21885866

If you know of a relevant reference for CID 5951923, please let us know.

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