Targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo; radiosensitizes human HT 1080 fibrosarcoma cells in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 710.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.41 mL||7.03 mL||14.07 mL|
|5 mM||0.28 mL||1.41 mL||2.81 mL|
|10 mM||0.14 mL||0.7 mL||1.41 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
References are publications that support the products' biological activity.
Lee and Mapp (2010) Transcriptional switches: chemical approaches to gene regulation. J.Biol.Chem. 285 11033 PMID: 20147748
Kung et al (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 33 PMID: 15261140
Staab et al (2007) Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer 13 213 PMID: 17999771
If you know of a relevant reference for Chetomin, please let us know.
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Keywords: Chetomin, supplier, NSC289491, p300/CBP, disrupts, interaction, HIF1a, HIF2a, STAT2, hypoxia, inducible, factors, hypoxic, gene, expression, HIF, Hypoxia, Inducible, Factors, HIF, Tocris Bioscience
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