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Targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo; radiosensitizes human HT 1080 fibrosarcoma cells in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in DMSO|
References are publications that support the biological activity of the product.
Lee and Mapp (2010) Transcriptional switches: chemical approaches to gene regulation. J.Biol.Chem. 285 11033 PMID: 20147748
Kung et al (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 33 PMID: 15261140
Staab et al (2007) Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer 13 213 PMID: 17999771
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Keywords: Chetomin, Chetomin supplier, NSC289491, p300/CBP, disrupts, interaction, HIF1a, HIF2a, STAT2, hypoxia, inducible, factors, hypoxic, gene, expression, Hypoxia, Inducible, Factors, 4705, Tocris Bioscience
1 Citation for Chetomin
Citations are publications that use Tocris products. Selected citations for Chetomin include:
Mousavizadeh et al (2016) Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts. J Physiol 594 2971 PMID: 26670924
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