Chetomin

Pricing Availability Delivery Time Qty
Cat.No. 4705 - Chetomin | C31H30N6O6S4 | CAS No. 1403-36-7
Description: Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
Chemical Name: (3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo; radiosensitizes human HT 1080 fibrosarcoma cells in vitro.

Technical Data

M. Wt 710.87
Formula C31H30N6O6S4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1403-36-7
PubChem ID 90488965
InChI Key ZRZWBWPDBOVIGQ-KIDIPURZSA-N
Smiles CN(C([C@@](CO)7N(C)C3=O)=O)[C@]3(SS7)CC2=CN([C@@]5(C[C@@](SS9)6C8=O)C4=CC=CC=C4N[C@@]([H])5N6C([C@@](CO)9N8C)=O)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 710.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.41 mL 7.03 mL 14.07 mL
5 mM 0.28 mL 1.41 mL 2.81 mL
10 mM 0.14 mL 0.7 mL 1.41 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lee and Mapp (2010) Transcriptional switches: chemical approaches to gene regulation. J.Biol.Chem. 285 11033 PMID: 20147748

Kung et al (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 33 PMID: 15261140

Staab et al (2007) Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer 13 213 PMID: 17999771


If you know of a relevant reference for Chetomin, please let us know.

Keywords: Chetomin, supplier, NSC289491, p300/CBP, disrupts, interaction, HIF1a, HIF2a, STAT2, hypoxia, inducible, factors, hypoxic, gene, expression, HIF, Hypoxia, Inducible, Factors, HIF, Tocris Bioscience

Citations for Chetomin

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Chetomin

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