CH 275

Pricing Availability Delivery Time Qty
Cat.No. 2454 - CH 275 | Cys-Lys-Phe-Phe-D-Trp-IAmp-Thr-Phe-Thr-Ser-Cys (Modifications: Cyclic Cys1-Cys11) | CAS No. 174688-78-9
Description: Potent and selective sst1 receptor agonist
Datasheet
Citations
Literature

Biological Activity

Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens.

Licensing Information

Sold with the permission of the SALK Institute.

Technical Data

M. Wt 1485.8
Formula C74H96N14O15S2
Sequence CKFFWXTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe)
Storage Store at -20°C
CAS Number 174688-78-9
PubChem ID 90488765
InChI Key LFOPEPKKBBIGHF-RXUBGYFDSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](NC(=O)[C@@H](CC2=CC=C(CNC(C)C)C=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.30 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1485.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.67 mL 3.37 mL 6.73 mL
5 mM 0.13 mL 0.67 mL 1.35 mL
10 mM 0.07 mL 0.34 mL 0.67 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (1999) Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem.Biophys.Res.Commun. 258 689 PMID: 10329447

Rivier et al (2001) Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J.Med.Chem. 44 2238 PMID: 11405660

Vasilaki et al (2004) The somatostatin receptor (sst1) modulates the release of somatostatin in the nucleus accumbens of the rat. Neuropharmacology 47 612 PMID: 15380378


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Keywords: CH 275, supplier, CH275, supplier, somatostatin, receptor, 1, sst1, sstr1, agonists, potent, selective, nucleus, accumbens, Somatostatin, Receptors, Tocris Bioscience

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