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Submit ReviewCH 275
Description: Potent and selective sst1 agonist
Biological Activity for CH 275
CH 275 is a potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens.
Licensing Information
Sold with the permission of the SALK Institute.
Technical Data for CH 275
| M. Wt | 1485.8 |
| Formula | C74H96N14O15S2 |
| Sequence | CKFFWXTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe) |
| Storage | Store at -20°C |
| CAS Number | 174688-78-9 |
| PubChem ID | 90488765 |
| InChI Key | LFOPEPKKBBIGHF-RXUBGYFDSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](NC(=O)[C@@H](CC2=CC=C(CNC(C)C)C=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CH 275
References for CH 275
References are publications that support the biological activity of the product.
Chen et al (1999) Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem.Biophys.Res.Commun. 258 689 PMID: 10329447
Rivier et al (2001) Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J.Med.Chem. 44 2238 PMID: 11405660
Vasilaki et al (2004) The somatostatin receptor (sst1) modulates the release of somatostatin in the nucleus accumbens of the rat. Neuropharmacology 47 612 PMID: 15380378
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Keywords: CH 275, CH 275 supplier, CH275, supplier, somatostatin, receptor, 1, sst1, sstr1, agonists, potent, selective, nucleus, accumbens, Somatostatin, Receptors, 2454, Tocris Bioscience
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