CH 275

Discontinued Product

CH 275 (Cat. No. 2454) has been withdrawn from sale for commercial reasons.
Description: Potent and selective sst1 agonist

Biological Activity for CH 275

CH 275 is a potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens.

Licensing Information

Sold with the permission of the SALK Institute.

Technical Data for CH 275

M. Wt 1485.8
Formula C74H96N14O15S2
Sequence CKFFWXTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe)
Storage Store at -20°C
CAS Number 174688-78-9
PubChem ID 90488765
Smiles [H]N[C@H]1CSSC[C@H](NC[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](NC(=O)[C@@H](CC2=CC=C(CNC(C)C)C=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for CH 275

Certificate of Analysis / Product Datasheet
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References for CH 275

References are publications that support the biological activity of the product.

Chen et al (1999) Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem.Biophys.Res.Commun. 258 689 PMID: 10329447

Rivier et al (2001) Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J.Med.Chem. 44 2238 PMID: 11405660

Vasilaki et al (2004) The somatostatin receptor (sst1) modulates the release of somatostatin in the nucleus accumbens of the rat. Neuropharmacology 47 612 PMID: 15380378

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Keywords: CH 275, CH 275 supplier, CH275, supplier, somatostatin, receptor, 1, sst1, sstr1, agonists, potent, selective, nucleus, accumbens, Somatostatin, Receptors, 2454, Tocris Bioscience

Citations for CH 275

Citations are publications that use Tocris products.

Currently there are no citations for CH 275.

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