CH 275

Pricing Availability Delivery Time Qty
Cat.No. 2454 - CH 275 | Cys-Lys-Phe-Phe-D-Trp-IAmp-Thr-Phe-Thr-Ser-Cys (Modifications: Cyclic Cys1-Cys11) | CAS No. 174688-78-9
Description: Potent and selective sst1 receptor agonist

Biological Activity

Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens.

Licensing Information

Sold with the permission of the SALK Institute.

Technical Data

M. Wt 1485.8
Formula C74H96N14O15S2
Sequence CKFFWXTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe)
Storage Store at -20°C
CAS Number 174688-78-9
PubChem ID 90488765
Smiles [H]N[C@H]1CSSC[C@H](NC[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](NC(=O)[C@@H](CC2=CC=C(CNC(C)C)C=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 0.30 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1485.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.67 mL 3.37 mL 6.73 mL
5 mM 0.13 mL 0.67 mL 1.35 mL
10 mM 0.07 mL 0.34 mL 0.67 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the biological activity of the product.

Chen et al (1999) Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem.Biophys.Res.Commun. 258 689 PMID: 10329447

Rivier et al (2001) Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J.Med.Chem. 44 2238 PMID: 11405660

Vasilaki et al (2004) The somatostatin receptor (sst1) modulates the release of somatostatin in the nucleus accumbens of the rat. Neuropharmacology 47 612 PMID: 15380378

If you know of a relevant reference for CH 275, please let us know.

View Related Products by Product Action

View all Somatostatin (sst) Receptor Agonists

Keywords: CH 275, CH 275 supplier, CH275, supplier, somatostatin, receptor, 1, sst1, sstr1, agonists, potent, selective, nucleus, accumbens, Somatostatin, Receptors, 2454, Tocris Bioscience

Citations for CH 275

Citations are publications that use Tocris products.

Currently there are no citations for CH 275. Do you know of a great paper that uses CH 275 from Tocris? Please let us know.

Reviews for CH 275

There are currently no reviews for this product. Be the first to review CH 275 and earn rewards!

Have you used CH 275?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.