Potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective. Also available as part of the Mixed NMDA Receptor Tocriset™.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 223.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.48 mL||22.4 mL||44.81 mL|
|5 mM||0.9 mL||4.48 mL||8.96 mL|
|10 mM||0.45 mL||2.24 mL||4.48 mL|
|50 mM||0.09 mL||0.45 mL||0.9 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bennett et al (1989) Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors. J.Pharmacol.Exp.Ther. 250 454 PMID: 2547931
Lehmann et al (1988) CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J.Pharmacol.Exp.Ther. 246 65 PMID: 2899170
Perez-Pinzon et al (1995) Correlation of CGS 19755 neuroprotection against in vivo excitotoxicity and focal cerebral ischemia. J.Cereb.Blood Flow Metab. 15 865 PMID: 7673380
If you know of a relevant reference for CGS 19755, please let us know.
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Keywords: CGS 19755, supplier, Potent, competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGS19755, NMDA, Receptors, Tocris Bioscience
4 Citations for CGS 19755
Citations are publications that use Tocris products. Selected citations for CGS 19755 include:
Jaekel et al (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. J Clin Invest 147 622 PMID: 16314856
Richardson and Shelton (2015) N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas. Cereb Cortex 352 156 PMID: 25368340
Pan et al (2014) Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. J Pharmacol Exp Ther 124 4629 PMID: 25202982
Pedrazzi et al (2012) Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein. PLoS One 7 e44518 PMID: 22952988
Do you know of a great paper that uses CGS 19755 from Tocris? If so please let us know.
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