CGS 19755

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Cat.No. 1241 - CGS 19755 | C7H14NO5P | CAS No. 110347-85-8
Description: Potent, competitive NMDA antagonist
Chemical Name: cis-4-[Phosphomethyl]-piperidine-2-carboxylic acid
Datasheet
Citations (4)
Literature

Biological Activity

Potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective. Also available as part of the Mixed NMDA Receptor Tocriset™.

Technical Data

M. Wt 223.17
Formula C7H14NO5P
Storage Store at RT
CAS Number 110347-85-8
PubChem ID 6604838
InChI Key LPMRCCNDNGONCD-NTSWFWBYSA-N
Smiles O=P(C[C@@H]1C[C@H]([C@](O)=O)NCC1)(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.58 25

Preparing Stock Solutions

The following data is based on the product molecular weight 223.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.48 mL 22.4 mL 44.81 mL
5 mM 0.9 mL 4.48 mL 8.96 mL
10 mM 0.45 mL 2.24 mL 4.48 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bennett et al (1989) Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors. J.Pharmacol.Exp.Ther. 250 454 PMID: 2547931

Lehmann et al (1988) CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J.Pharmacol.Exp.Ther. 246 65 PMID: 2899170

Perez-Pinzon et al (1995) Correlation of CGS 19755 neuroprotection against in vivo excitotoxicity and focal cerebral ischemia. J.Cereb.Blood Flow Metab. 15 865 PMID: 7673380


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Keywords: CGS 19755, supplier, Potent, competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGS19755, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

4 Citations for CGS 19755

Citations are publications that use Tocris products. Selected citations for CGS 19755 include:

Pan et al (2014) Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. J Pharmacol Exp Ther 124 4629 PMID: 25202982

Pedrazzi et al (2012) Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein. PLoS One 7 e44518 PMID: 22952988

Richardson and Shelton (2015) N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas. Cereb Cortex 352 156 PMID: 25368340

Jaekel et al (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. J Clin Invest 147 622 PMID: 16314856


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