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CGP 60474

Cat. No. 5471 Submit a Review Datasheet / COA / SDS
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Cat.No. 5471 - CGP 60474 | C18H18ClN5O | CAS No. 164658-13-3
Description: Potent dual cdk1/cdk2 inhibitor
Chemical Name: 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent dual cdk1/cdk2 inhibitor (IC50 values are 20 and 50 nM, respectively). Also displays low micromolar activity at PKCα. Displays reversible G1/S cell cycle arrest in U2-OS cells.

Compound Libraries

CGP 60474 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 355.82
Formula C18H18ClN5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 164658-13-3
PubChem ID 644215
InChI Key IYNDTACKOAXKBJ-UHFFFAOYSA-N
Smiles OCCCNC1=NC=CC(C2=NC(NC3=CC(Cl)=CC=C3)=NC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.58 100
1eq. HCl 17.79 50

Preparing Stock Solutions

The following data is based on the product molecular weight 355.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.05 mL 28.1 mL
5 mM 0.56 mL 2.81 mL 5.62 mL
10 mM 0.28 mL 1.41 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Stanetty et al (2005) Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J.Org.Chem. 70 5215 PMID: 15960526

Sielecki et al (2000) Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation. J.Med.Chem. 43 1 PMID: 10633033

If you know of a relevant reference for CGP 60474, please let us know.

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Citations for CGP 60474

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