CGP 39551

Pricing Availability   Qty
Description: Potent, selective and competitive NMDA antagonist
Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (6)

Biological Activity for CGP 39551

CGP 39551 is a potent, selective and competitive NMDA antagonist (Ki = 310 nM for inhibition of [3H]-CPP binding in rat brain). Centrally active upon oral administration in vivo.

Technical Data for CGP 39551

M. Wt 237.19
Formula C8H16NO5P
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 127910-32-1
PubChem ID 6372334
InChI Key OKDOWCKDTWNRCB-GQCTYLIASA-N
Smiles NC(C(OCC)=O)/C=C(C)/CP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CGP 39551

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.72 100

Preparing Stock Solutions for CGP 39551

The following data is based on the product molecular weight 237.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.22 mL 21.08 mL 42.16 mL
5 mM 0.84 mL 4.22 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.22 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets for CGP 39551

Certificate of Analysis / Product Datasheet
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References for CGP 39551

References are publications that support the biological activity of the product.

D'Hooge et al (1999) Effects of competitive NMDA receptor antagonists on excitatory amino-acid-evoked currents in mouse spinal cord. Fundam.Clin.Pharmacol. 13 67 PMID: 10027090

Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-MthD.-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791 PMID: 1972895

Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-MthD.-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamaz. J.Pharmacol.Exp.Ther. 256 432 PMID: 1671593


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View all NMDA Receptor Antagonists

Keywords: CGP 39551, CGP 39551 supplier, Potent, selective, competitive, NMDA, antagonist, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGP39551, 1409, Tocris Bioscience

2 Citations for CGP 39551

Citations are publications that use Tocris products. Selected citations for CGP 39551 include:

Bäckström and Hyytiä (2006) Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31 778 PMID: 16123768

Grieder et al (2012) Phasic D1 and tonic D2 DA receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proc Natl Acad Sci U S A 109 3101 PMID: 22308372


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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