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Description: Potent, selective and competitive NMDA antagonist
Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester
Purity: ≥98% (HPLC)
Biological Activity for CGP 39551
CGP 39551 is a potent, selective and competitive NMDA antagonist (Ki = 310 nM for inhibition of [3H]-CPP binding in rat brain). Centrally active upon oral administration in vivo.
Technical Data for CGP 39551
| M. Wt | 237.19 |
| Formula | C8H16NO5P |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 127910-32-1 |
| PubChem ID | 6372334 |
| InChI Key | OKDOWCKDTWNRCB-GQCTYLIASA-N |
| Smiles | NC(C(OCC)=O)/C=C(C)/CP(O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CGP 39551
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.72 | 100 |
Preparing Stock Solutions for CGP 39551
The following data is based on the product molecular weight 237.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.22 mL | 21.08 mL | 42.16 mL |
| 5 mM | 0.84 mL | 4.22 mL | 8.43 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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Product Datasheets for CGP 39551
References for CGP 39551
References are publications that support the biological activity of the product.
D'Hooge et al (1999) Effects of competitive NMDA receptor antagonists on excitatory amino-acid-evoked currents in mouse spinal cord. Fundam.Clin.Pharmacol. 13 67 PMID: 10027090
Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-MthD.-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791 PMID: 1972895
Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-MthD.-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamaz. J.Pharmacol.Exp.Ther. 256 432 PMID: 1671593
If you know of a relevant reference for CGP 39551, please let us know.
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Keywords: CGP 39551, CGP 39551 supplier, Potent, selective, competitive, NMDA, antagonist, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGP39551, 1409, Tocris Bioscience
2 Citations for CGP 39551
Citations are publications that use Tocris products. Selected citations for CGP 39551 include:
Grieder et al (2012) Phasic D1 and tonic D2 DA receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proc Natl Acad Sci U S A 109 3101 PMID: 22308372
Bäckström and Hyytiä (2006) Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31 778 PMID: 16123768
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