CGP 37849

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Cat.No. 1469 - CGP 37849 | C6H12NO5P | CAS No. 127910-31-0
Description: Potent and selective NMDA antagonist
Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Anticonvulsive following oral administration in vivo.

Technical Data

M. Wt 209.14
Formula C6H12NO5P
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 127910-31-0
PubChem ID 5950212
InChI Key BDYHNCZIGYIOGJ-DUXPYHPUSA-N
Smiles NC(C(O)=O)/C=C(C)/CP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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References

References are publications that support the biological activity of the product.

Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791 PMID: 1972895

Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. J.Pharmacol.Exp.Ther. 256 432 PMID: 1671593

Pozza et al (1990) Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551. Eur.J.Pharmacol. 182 91 PMID: 1976098


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Keywords: CGP 37849, CGP 37849 supplier, Potent, selective, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGP37849, 1469, Tocris Bioscience

3 Citations for CGP 37849

Citations are publications that use Tocris products. Selected citations for CGP 37849 include:

Kim et al (2012) Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1. J Neurophysiol 108 1965 PMID: 22773781

Sowa et al (2015) Prenatal stress enhances excitatory synaptic transmission and impairs long-term potentiation in the frontal cortex of adult offspring rats. PLoS One 10 e0119407 PMID: 25749097

Owen and Grover (2015) Activity-dependent differences in function between proximal and distal Schaffer collaterals. J Neurophysiol 113 3646 PMID: 25855695


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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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