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Cerulenin

Cat. No. 6702 Submit a Review Datasheet / COA / SDS
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Description: Irreversible fatty acid synthase inhibitor
Chemical Name: (2R,3S)-3-[(4E,7E)-1-Oxo-4,7-nonadien-1-yl]-2-oxiranecarboxamide
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Cerulenin

Cerulenin is an irreversible fatty acid synthase inhibitor. Blocks proliferation of KRAS-driven lung cancer cells. Promotes apoptosis and inhibits necroptosis in cancer cells. Also inhibits protein palmitoylation and insulin uptake in rat adipocytes in vitro. Antibiotic.

Technical Data for Cerulenin

M. Wt 223.27
Formula C12H17NO3
Storage Store at -20°C
CAS Number 17397-89-6
PubChem ID 5282054
InChI Key GVEZIHKRYBHEFX-NQQPLRFYSA-N
Smiles C/C=C/C/C=C/CCC([C@H]1O[C@H]1C(N)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cerulenin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.33 100
ethanol 22.33 100

Preparing Stock Solutions for Cerulenin

The following data is based on the product molecular weight 223.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.48 mL 22.39 mL 44.79 mL
5 mM 0.9 mL 4.48 mL 8.96 mL
10 mM 0.45 mL 2.24 mL 4.48 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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References for Cerulenin

References are publications that support the biological activity of the product.

Gouw et al (2017) Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma. Proc.Natl.Acad.Sci.U.S.A. 114 4300 PMID: 28400509

Parisi et al (2017) Very long chain fatty acids are functionally involved in necroptosis. Cell Chem.Bio. 24 1445 PMID: 29033315

Jochen et al (1995) Inhibitory effects of cerulenin on protein palmitoylation and Ins internalization in rat adipocytes. Biochim.Biophys.Acta. 1259 65 PMID: 7492617

If you know of a relevant reference for Cerulenin, please let us know.

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Keywords: Cerulenin, Cerulenin supplier, fatty, acid, synthase, FASN, inhibitor, inhibits, irreversible, Fatty, Acid, Synthase, Antibiotics, 6702, Tocris Bioscience

Citations for Cerulenin

Citations are publications that use Tocris products.

Currently there are no citations for Cerulenin. Do you know of a great paper that uses Cerulenin from Tocris? Please let us know.

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Literature in this Area

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Cancer Research Product Guide

Cancer Research Product Guide

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