Ceftriaxone disodium salt

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Cat.No. 3732 - Ceftriaxone disodium salt | C18H16N8Na2O7S3 | CAS No. 104376-79-6
Description: Neuroprotective; increases EAAT2 expression and activity
Chemical Name: 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
Purity: ≥98% (HPLC)
Reviews (2)

Biological Activity

β-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.

Technical Data

M. Wt 598.54
Formula C18H16N8Na2O7S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 104376-79-6
PubChem ID 9601224
Smiles [Na+].[Na+].CO\N=C(/C(=O)NC1C(=O)N2C(C([O-])=O)=C(CSC3=NC(=O)C([O-])=NN3C)CS[C@]12[H])C1=CSC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.93 50

Preparing Stock Solutions

The following data is based on the product molecular weight 598.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.34 mL 16.71 mL 33.41 mL
2.5 mM 0.67 mL 3.34 mL 6.68 mL
5 mM 0.33 mL 1.67 mL 3.34 mL
25 mM 0.07 mL 0.33 mL 0.67 mL

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References are publications that support the biological activity of the product.

Rothstein et al (2005) β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 73 PMID: 15635412

Rawls et al (2007) The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Br.J.Pharmacol. 151 1095 PMID: 17592517

Lipski et al (2007) Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience 146 617 PMID: 17363173

If you know of a relevant reference for Ceftriaxone disodium salt, please let us know.

Keywords: Ceftriaxone disodium salt, Ceftriaxone disodium salt supplier, GLT-1, EAAT2, glutamate, transporters, activators, expression, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitter, antibiotics, Glutamate, Antibiotics, 3732, Tocris Bioscience

Citations for Ceftriaxone disodium salt

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Reviews for Ceftriaxone disodium salt

Average Rating: 4.5 (Based on 2 Reviews.)

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Worked well: Good publishable, would use again.
By Anonymous on 09/18/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: iPSC derived human astrocytes

Added to cells in vitro

Increase GLT1 expression: Excellent publishable, performed ideally.
By Anonymous on 01/25/2018
Species: Human

Used it to increase protein expression of GLT1 in mouse brain. It worked very well and easily dissolves in saline.

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