Ceftriaxone disodium salt
β-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 598.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.34 mL||16.71 mL||33.41 mL|
|2.5 mM||0.67 mL||3.34 mL||6.68 mL|
|5 mM||0.33 mL||1.67 mL||3.34 mL|
|25 mM||0.07 mL||0.33 mL||0.67 mL|
References are publications that support the biological activity of the product.
Rothstein et al (2005) β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 73 PMID: 15635412
Rawls et al (2007) The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Br.J.Pharmacol. 151 1095 PMID: 17592517
Lipski et al (2007) Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience 146 617 PMID: 17363173
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Keywords: Ceftriaxone disodium salt, Ceftriaxone disodium salt supplier, GLT-1, EAAT2, glutamate, transporters, activators, expression, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitter, antibiotics, Glutamate, Antibiotics, 3732, Tocris Bioscience
Citations for Ceftriaxone disodium salt
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Added to cells in vitro
Used it to increase protein expression of GLT1 in mouse brain. It worked very well and easily dissolves in saline.
Literature in this Area
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Huntington's Disease Poster
Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.