Ceftriaxone disodium salt

Pricing Availability Delivery Time Qty
Cat.No. 3732 - Ceftriaxone disodium salt | C18H16N8Na2O7S3 | CAS No. 104376-79-6
Description: Neuroprotective; increases EAAT2 expression and activity
Chemical Name: 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

β-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.

Technical Data

M. Wt 598.54
Formula C18H16N8Na2O7S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 104376-79-6
PubChem ID 9601224
InChI Key FDRNWTJTHBSPMW-ZJTMPOFJSA-L
Smiles [Na+].[Na+].CO\N=C(/C(=O)NC1C(=O)N2C(C([O-])=O)=C(CSC3=NC(=O)C([O-])=NN3C)CS[C@]12[H])C1=CSC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.93 50

Preparing Stock Solutions

The following data is based on the product molecular weight 598.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.67 mL 8.35 mL 16.71 mL
5 mM 0.33 mL 1.67 mL 3.34 mL
10 mM 0.17 mL 0.84 mL 1.67 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rothstein et al (2005) β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 73 PMID: 15635412

Rawls et al (2007) The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Br.J.Pharmacol. 151 1095 PMID: 17592517

Lipski et al (2007) Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience 146 617 PMID: 17363173


If you know of a relevant reference for Ceftriaxone disodium salt, please let us know.

Keywords: GLT-1 EAAT2 glutamate transporters activators expression Excitatory Amino Acid Transporters Monoamine Neurotransmitter antibiotics Glutamate Transporters

Citations for Ceftriaxone disodium salt

Citations are publications that use Tocris products.

Currently there are no citations for Ceftriaxone disodium salt. Do you know of a great paper that uses Ceftriaxone disodium salt from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Huntington's Disease

Huntington's Disease Poster

Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Pathways for Ceftriaxone disodium salt

Protocols

TODO: Add Protocols