CBMR 0083

Pricing Availability   Qty
Description: Potent allosteric FFA1 (GPR40) and 4 (GPR120) agonist
Chemical Name: 1-[3-[[4-Amino-6-[[2-(2,5-dichlorophenyl)ethyl]amino]-1,3,5-triazin-2-yl]methoxy]-5-methylphenyl]-2-pyrrolidinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for CBMR 0083

CBMR 0083 is a potent allosteric free fatty acid receptor 1 (FFA1) and 4 (FFA4) agonist (EC50 values are 1 and 2 nM for FFA1 and FFA4, respectively).

Technical Data for CBMR 0083

M. Wt 487.39
Formula C23H24Cl2N6O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2839486-16-5
PubChem ID 167312323
InChI Key AIIZGUNRDJPXHF-UHFFFAOYSA-N
Smiles O=C1N(CCC1)C2=CC(OCC3=NC(NCCC4=CC(Cl)=CC=C4Cl)=NC(N)=N3)=CC(C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CBMR 0083

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.74 100

Preparing Stock Solutions for CBMR 0083

The following data is based on the product molecular weight 487.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.26 mL 20.52 mL
5 mM 0.41 mL 2.05 mL 4.1 mL
10 mM 0.21 mL 1.03 mL 2.05 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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References for CBMR 0083

References are publications that support the biological activity of the product.

Lückmann et al (2022) Optimization of first-in-class dual-acting FFAR1/FFAR4 allosteric modulators with novel mode of action. ACS Med.Chem.Lett. 13 1839 PMID: 36518697


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Keywords: CBMR 0083, CBMR 0083 supplier, CBMR0083, free, fatty, acid, receptor, FFA, FFA1, FFA4, GPR40, GPR120, G-protein-coupled, GPCR, allosteric, modulators, agonists, modulator, agonist, Free, Fatty, Acid, Receptors, 7890, Tocris Bioscience

Citations for CBMR 0083

Citations are publications that use Tocris products.

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