CB 13

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Cat.No. 2928 - CB 13 | C26H24O2 | CAS No. 432047-72-8
Description: Potent dual CB1/CB2 agonist
Chemical Name: 1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent, orally active CB1/CB2 receptor agonist with limited brain penetration (EC50 values are 6.1 and 27.9 nM for CB1 and CB2 receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.

Technical Data

M. Wt 368.47
Formula C26H24O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 432047-72-8
PubChem ID 9799417
InChI Key RSUMDJRTAFBISX-UHFFFAOYSA-N
Smiles O=C(C3=CC=CC4=C3C=CC=C4)C2=CC=C(OCCCCC)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.85 100
ethanol 18.42 50

Preparing Stock Solutions

The following data is based on the product molecular weight 368.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.57 mL 27.14 mL
5 mM 0.54 mL 2.71 mL 5.43 mL
10 mM 0.27 mL 1.36 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Dziadulewicz et al (2007) Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J.Med.Chem. 50 3851 PMID: 17630726

Cluny et al (2010) Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice. J.Pharmacol.Exp.Ther. 334 973 PMID: 20571060


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Keywords: CB 13, supplier, Potent, dual, CB1/CB2, agonists, cannabinoids, Non-Selective, Receptors, CB13, cb2r, cb1r, Non-selective, Cannabinoids, Non-selective, Cannabinoids, Tocris Bioscience

1 Citation for CB 13

Citations are publications that use Tocris products. Selected citations for CB 13 include:

Alvarez-Fuentes et al (2012) Development and validation of an RP-HPLC method for CB13 evaluation in several PLGA nanoparticle systems. ScientificWorldJournal 2012 737526 PMID: 22792051


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