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Description: FFA2 (GPR43) inverse agonist
Chemical Name: (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid
Purity: ≥98% (HPLC)

Biological Activity for CATPB

CATPB is a FFA2 inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.

Technical Data for CATPB

M. Wt 399.79
Formula C19H17ClF3NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1322598-09-3
PubChem ID 53308747
Smiles OC(C[C@@H](NC(CC1=CC=CC(Cl)=C1)=O)CC2=CC=C(C(F)(F)F)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CATPB

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.98 100
ethanol 19.99 50

Preparing Stock Solutions for CATPB

The following data is based on the product molecular weight 399.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.51 mL 25.01 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for CATPB

References are publications that support the biological activity of the product.

Park et al (2016) Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 771 1 PMID: 26683635

Sergeev et al (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 291 303 PMID: 26518871

If you know of a relevant reference for CATPB, please let us know.

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Citations for CATPB

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