Carboxy-PTIO, potassium salt

Discontinued Product

Carboxy-PTIO, potassium salt (Cat. No. 0772) has been withdrawn from sale for commercial reasons.
Cat.No. 0772 - Carboxy-PTIO, potassium salt | C14H16KN2O4 | CAS No. 148819-94-7
Description: Stable, water-soluble deactivator of NO
Chemical Name: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt
Citations (11)
Literature (1)

Biological Activity

A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.

Technical Data

M. Wt 315.38
Formula C14H16KN2O4
Storage Desiccate at -20°C
CAS Number 148819-94-7
PubChem ID 2733502
Smiles [K+].CC1(C)N([O])C(C2=CC=C(C=C2)C([O-])=O)=[N+]([O-])C1(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:


References are publications that support the biological activity of the product.

Akaike et al (1993) Antagonistic action of imidazolineoxy N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32 827 PMID: 8422387

Rand and Li (1995) Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Br.J.Pharmacol. 116 1906 PMID: 8528578

Tsunoda et al (1994) Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. Eur.J.Pharmacol. 262 55 PMID: 7813579

View Related Products by Target

Keywords: Carboxy-PTIO, potassium salt, Carboxy-PTIO, potassium salt supplier, Stable, water-soluble, deactivators, NO, Nitric, Oxide, Signaling, Signalling, free, radical, Other, 0772, Tocris Bioscience

11 Citations for Carboxy-PTIO, potassium salt

Citations are publications that use Tocris products. Selected citations for Carboxy-PTIO, potassium salt include:

Jin et al (2012) Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol 16 211 PMID: 22802704

Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. Learn Mem 17 221 PMID: 20351057

Ping and Schafe (2010) The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses. Neural Plast 2010 540940 PMID: 21461354

Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning. PLoS One 5 e11236 PMID: 20574537

Reviews for Carboxy-PTIO, potassium salt

There are currently no reviews for this product. Be the first to review Carboxy-PTIO, potassium salt and earn rewards!

Have you used Carboxy-PTIO, potassium salt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis