Carboxy-PTIO, potassium salt

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Cat.No. 0772 - Carboxy-PTIO, potassium salt | C14H16KN2O4 | CAS No. 148819-94-7
Description: Stable, water-soluble deactivator of NO
Chemical Name: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt
Datasheet
Citations (8)
Literature

Biological Activity

A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.

Technical Data

M. Wt 315.38
Formula C14H16KN2O4
Storage Desiccate at -20°C
CAS Number 148819-94-7
PubChem ID 2733502
InChI Key VYEUQMVIGXFZQU-UHFFFAOYSA-M
Smiles [K+].CC1(C)N([O])C(C2=CC=C(C=C2)C([O-])=O)=[N+]([O-])C1(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 25 mM in ethanol and to 10 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 315.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.85 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Akaike et al (1993) Antagonistic action of imidazolineoxy N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32 827 PMID: 8422387

Rand and Li (1995) Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Br.J.Pharmacol. 116 1906 PMID: 8528578

Tsunoda et al (1994) Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. Eur.J.Pharmacol. 262 55 PMID: 7813579


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Keywords: Carboxy-PTIO, potassium salt, supplier, Stable, water-soluble, deactivators, NO, Nitric, Oxide, Signaling, Signalling, free, radical, Other, Nitric, Oxide, Other, Nitric, Oxide, Tocris Bioscience

8 Citations for Carboxy-PTIO, potassium salt

Citations are publications that use Tocris products. Selected citations for Carboxy-PTIO, potassium salt include:

Clark et al (2015) Selective activation of microglia facilitates synaptic strength. Cardiovasc Res 35 4552 PMID: 25788673

Echeverría et al (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One 9 e94146 PMID: 24710004

Jin et al (2012) Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol 16 211 PMID: 22802704

Quock et al (2011) The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice. Brain Res 1368 102 PMID: 20977894

Ormerod et al (2011) The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Br J Pharmacol 89 560 PMID: 20889759

Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. Learn Mem 17 221 PMID: 20351057

Ping and Schafe (2010) The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses. Neural Plast 2010 540940 PMID: 21461354

Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning. PLoS One 5 e11236 PMID: 20574537


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