Carboxy-PTIO, potassium salt
A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 25 mM in ethanol and to 10 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 315.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.17 mL||15.85 mL||31.71 mL|
|5 mM||0.63 mL||3.17 mL||6.34 mL|
|10 mM||0.32 mL||1.59 mL||3.17 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Akaike et al (1993) Antagonistic action of imidazolineoxy N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32 827 PMID: 8422387
Rand and Li (1995) Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Br.J.Pharmacol. 116 1906 PMID: 8528578
Tsunoda et al (1994) Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. Eur.J.Pharmacol. 262 55 PMID: 7813579
If you know of a relevant reference for Carboxy-PTIO, potassium salt, please let us know.
Keywords: Stable water-soluble deactivators NO Nitric Oxide Signaling Signalling free radical Other Nitric Oxide
8 Citations for Carboxy-PTIO, potassium salt
Citations are publications that use Tocris products. Selected citations for Carboxy-PTIO, potassium salt include:
Clark et al (2015) Selective activation of microglia facilitates synaptic strength. Cardiovasc Res 35 4552 PMID: 25788673
Echeverría et al (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One 9 e94146 PMID: 24710004
Jin et al (2012) Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol 16 211 PMID: 22802704
Quock et al (2011) The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice. Brain Res 1368 102 PMID: 20977894
Ormerod et al (2011) The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Br J Pharmacol 89 560 PMID: 20889759
Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. Learn Mem 17 221 PMID: 20351057
Ping and Schafe (2010) The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses. Neural Plast 2010 540940 PMID: 21461354
Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning. PLoS One 5 e11236 PMID: 20574537
Do you know of a great paper that uses Carboxy-PTIO, potassium salt from Tocris? If so please let us know.