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CB2 and CB1 receptor agonist (Ki values are 126 and 211 nM respectively). Inhibits adenylyl cyclase (EC50 values are 120 and 261 nM for CB1 and CB2 receptors respectively) and suppresses immune cell function. Major constituent of cannabis; displays little or no psychotropic activity.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 310.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.44 mL||32.21 mL||64.43 mL|
|2.5 mM||1.29 mL||6.44 mL||12.89 mL|
|5 mM||0.64 mL||3.22 mL||6.44 mL|
|25 mM||0.13 mL||0.64 mL||1.29 mL|
References are publications that support the biological activity of the product.
Rhee et al (1997) Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylyl cyclase. J.Med.Chem. 40 3228 PMID: 9379442
Herring et al (1998) Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kB elements by cannabinol, a minimally CNS-active cannabinoid. Biochem.Pharmacol. 55 1013 PMID: 9605425
Zygmunt et al (2002) Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. J.Neurosci. 22 4720 PMID: 12040079
If you know of a relevant reference for Cannabinol, please let us know.
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Keywords: Cannabinol, Cannabinol supplier, cannabinoids, CB1, CB2, receptors, agonists, not, psychoactive, CBN, Non-selective, Cannabinoids, 3130, Tocris Bioscience
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Literature in this Area
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