Cannabinol

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Cat.No. 3130 - Cannabinol | C21H26O2 | CAS No. 521-35-7
Description: Cannabinoid receptor agonist; not psychoactive
Alternative Names: CBN
Chemical Name: 6,6,9-Trimethyl-3-pentyl-6H-benzo[c]chromen-1-ol
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

CB2 and CB1 receptor agonist (Ki values are 126 and 211 nM respectively). Inhibits adenylyl cyclase (EC50 values are 120 and 261 nM for CB1 and CB2 receptors respectively) and suppresses immune cell function. Major constituent of cannabis; displays little or no psychotropic activity.

Technical Data

M. Wt 310.43
Formula C21H26O2
Storage Store at -20°C
CAS Number 521-35-7
PubChem ID 2543
InChI Key VBGLYOIFKLUMQG-UHFFFAOYSA-N
Smiles CC1=CC2=C(C(C)(C)OC3=C2C(O)=CC(CCCCC)=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.52 50
ethanol 3.1 10

Preparing Stock Solutions

The following data is based on the product molecular weight 310.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.44 mL 32.21 mL 64.43 mL
2.5 mM 1.29 mL 6.44 mL 12.89 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
25 mM 0.13 mL 0.64 mL 1.29 mL

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Product Datasheets

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References

References are publications that support the biological activity of the product.

Rhee et al (1997) Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylyl cyclase. J.Med.Chem. 40 3228 PMID: 9379442

Herring et al (1998) Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kB elements by cannabinol, a minimally CNS-active cannabinoid. Biochem.Pharmacol. 55 1013 PMID: 9605425

Zygmunt et al (2002) Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. J.Neurosci. 22 4720 PMID: 12040079


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Citations for Cannabinol

Citations are publications that use Tocris products.

Currently there are no citations for Cannabinol. Do you know of a great paper that uses Cannabinol from Tocris? Please let us know.

Reviews for Cannabinol

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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