c-Di-GMP sodium salt
Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.
This product is sold in units of 730μg, equivalent to 1μmol.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 734.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.36 mL||6.81 mL||13.62 mL|
|5 mM||0.27 mL||1.36 mL||2.72 mL|
|10 mM||0.14 mL||0.68 mL||1.36 mL|
|50 mM||0.03 mL||0.14 mL||0.27 mL|
References are publications that support the products' biological activity.
Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat.Immunol. 13 1155 PMID: 23142775
Burdette et al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515 PMID: 21947006
Nakamura et al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149 PMID: 26282097
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Keywords: c-Di-GMP sodium salt, supplier, STING, DDX41, ligands, activates, activators, cancer, immunotherapy, 61093-23-0, STING-Dependent, Signaling, STING-Dependent, Signaling, Tocris Bioscience
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