c-Di-GMP sodium salt

Pricing Availability Delivery Time Qty
Cat.No. 5900 - c-Di-GMP sodium salt | C20H22N10Na2O14P2
Description: Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Chemical Name: 3',5'-Cyclic diguanylic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.

This product is sold in units of 730μg, equivalent to 1μmol.

Technical Data

M. Wt 734.37
Formula C20H22N10Na2O14P2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 101199074
InChI Key SVIXOIGPVFFABR-XDODWTFASA-L
Smiles O=P(O[C@H]1[C@H]([C@H](N6C=NC7=C6N=C(NC7=O)N)O[C@@H]1CO2)O)(O[Na])OC[C@@H]3[C@H]([C@H]([C@H](N4C=NC5=C4N=C(NC5=O)N)O3)O)OP2(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.69 20

Preparing Stock Solutions

The following data is based on the product molecular weight 734.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.36 mL 6.81 mL 13.62 mL
5 mM 0.27 mL 1.36 mL 2.72 mL
10 mM 0.14 mL 0.68 mL 1.36 mL
50 mM 0.03 mL 0.14 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat.Immunol. 13 1155 PMID: 23142775

Burdette et al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515 PMID: 21947006

Nakamura et al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149 PMID: 26282097


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Citations for c-Di-GMP sodium salt

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Literature in this Area

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Immunology

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