c-Di-GMP sodium salt

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Description: Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Chemical Name: 3',5'-Cyclic diguanylic acid sodium salt
Purity: ≥98% (HPLC)

Biological Activity for c-Di-GMP sodium salt

c-Di-GMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.

This product is sold in units of 730μg, equivalent to 1μmol.

Technical Data for c-Di-GMP sodium salt

M. Wt 734.37
Formula C20H22N10Na2O14P2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2222132-40-1
PubChem ID 101199074
Smiles O=P(O[C@H]1[C@H]([C@H](N6C=NC7=C6N=C(NC7=O)N)O[C@@H]1CO2)O)(O[Na])OC[C@@H]3[C@H]([C@H]([C@H](N4C=NC5=C4N=C(NC5=O)N)O3)O)OP2(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for c-Di-GMP sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 14.69 20

Preparing Stock Solutions for c-Di-GMP sodium salt

The following data is based on the product molecular weight 734.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.81 mL 34.04 mL 68.09 mL
1 mM 1.36 mL 6.81 mL 13.62 mL
2 mM 0.68 mL 3.4 mL 6.81 mL
10 mM 0.14 mL 0.68 mL 1.36 mL

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Product Datasheets for c-Di-GMP sodium salt

Certificate of Analysis / Product Datasheet
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References for c-Di-GMP sodium salt

References are publications that support the biological activity of the product.

Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 13 1155 PMID: 23142775

Burdette et al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515 PMID: 21947006

Nakamura et al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149 PMID: 26282097

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Keywords: c-Di-GMP sodium salt, c-Di-GMP sodium salt supplier, STING, DDX41, ligands, activates, activators, cancer, immunotherapy, 61093-23-0, STING-Dependent, Signaling, 5900, Tocris Bioscience

Citations for c-Di-GMP sodium salt

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