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c-Di-AMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also A2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34+ cells.
This product is sold in units of 702μg, equivalent to 1μmol.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 702.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||7.12 mL||35.59 mL||71.19 mL|
|1 mM||1.42 mL||7.12 mL||14.24 mL|
|2 mM||0.71 mL||3.56 mL||7.12 mL|
|10 mM||0.14 mL||0.71 mL||1.42 mL|
References are publications that support the biological activity of the product.
Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 13 1155 PMID: 23142775
Tosolini et al (2015) Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol.Cell.Biol. 35 479 PMID: 25384972
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Keywords: c-Di-AMP sodium salt, c-Di-AMP sodium salt supplier, STING, DDX41, ligands, activates, activators, adenosine, A2A, receptors, inverse, agonists, agonism, apoptosis, Adenosine, Receptors, STING-Dependent, Signaling, 5901, Tocris Bioscience
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Induction of type I IFNs with c-di-AMP was studied in a variety ofcell lines. The human monocytic cell line THP-1 has been shown to expressall the CDSs4-6 with the exception of DAI.
Make sure to resuspend c-di-AMP and stimulate cells with 1-100 mg/ml c-di-AMP for 16-48 hours. Monitor induction of type I IFNs by measuring the levels of IRF-induced Lucia luciferase in the cell culture supernatant
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