c-Di-AMP sodium salt
Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also A2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34+ cells.
This product is sold in units of 702μg, equivalent to 1μmol.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 702.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.42 mL||7.12 mL||14.24 mL|
|5 mM||0.28 mL||1.42 mL||2.85 mL|
|10 mM||0.14 mL||0.71 mL||1.42 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
References are publications that support the biological activity of the product.
Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat.Immunol. 13 1155 PMID: 23142775
Tosolini et al (2015) Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol.Cell.Biol. 35 479 PMID: 25384972
If you know of a relevant reference for c-Di-AMP sodium salt, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: c-Di-AMP sodium salt, c-Di-AMP sodium salt supplier, STING, DDX41, ligands, activates, activators, adenosine, A2A, receptors, inverse, agonists, agonism, apoptosis, Adenosine, Receptors, STING-Dependent, Signaling, 5901, Tocris Bioscience
Citations for c-Di-AMP sodium salt
Citations are publications that use Tocris products.
Currently there are no citations for c-Di-AMP sodium salt. Do you know of a great paper that uses c-Di-AMP sodium salt from Tocris? Please let us know.
Reviews for c-Di-AMP sodium salt
There are currently no reviews for this product. Be the first to review c-Di-AMP sodium salt and earn rewards!
Have you used c-Di-AMP sodium salt?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.