C 21

Discontinued Product

C 21 (Cat. No. 5128) has been withdrawn from sale for commercial reasons.
Description: Selective PRMT1 inhibitor
Literature (1)

Biological Activity for C 21

C 21 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.

Technical Data for C 21

M. Wt 2166.94
Formula C90H161ClN36O24

(Modifications: Ser-1 = N-terminal Ac, X = N5-(2-Chloro-1-iminoethyl)]-Orn)

Storage Store at -20°C
CAS Number 1229236-78-5
PubChem ID 46911727

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for C 21

Certificate of Analysis / Product Datasheet
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References for C 21

References are publications that support the biological activity of the product.

Obianyo et al (2010) A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem 11 1219 PMID: 20480486

Obianyo and Thompson (2012) Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J.Biol.Chem. 287 6062 PMID: 22219200

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Keywords: C 21, C 21 supplier, C21, selective, protein, arginine, methyltransferases, inhibitors, inhibits, PRMT1, epigenetics, histone, transferases, Protein, Arginine, Methyltransferases, 5128, Tocris Bioscience

Citations for C 21

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Currently there are no citations for C 21.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.