BS 181 dihydrochloride

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Cat.No. 5608 - BS 181 dihydrochloride | C22H32N6.2HCl
Description: Selective cdk7 inhibitor
Chemical Name: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over others cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

Compound Libraries

BS 181 dihydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 453.45
Formula C22H32N6.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
PubChem ID 91826108
InChI Key XYXAMTBYYTXHSO-UHFFFAOYSA-N
Smiles CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.34 100
ethanol 22.67 50
water 45.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 453.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.03 mL 22.05 mL
5 mM 0.44 mL 2.21 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208 PMID: 19638587


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View all Cyclin-Dependent Protein Kinase Inhibitors

Keywords: BS 181 dihydrochloride, supplier, cyclin-dependent, kinase, 7, cdk7, BS-181, inhibitors, cancer, apoptosis, activating, 1397219-81-6, inhibits, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience

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Cell Cycle & DNA Damage Repair

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.