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BS 181 dihydrochloride

Cat. No. 5608 Submit a Review Datasheet / COA / SDS
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Cat.No. 5608 - BS 181 dihydrochloride | C22H32N6.2HCl
Description: Selective cdk7 inhibitor
Chemical Name: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over others cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

Compound Libraries

BS 181 dihydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 453.45
Formula C22H32N6.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
PubChem ID 91826108
InChI Key XYXAMTBYYTXHSO-UHFFFAOYSA-N
Smiles CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.34 100
DMSO 45.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 453.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.03 mL 22.05 mL
5 mM 0.44 mL 2.21 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208 PMID: 19638587

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Citations for BS 181 dihydrochloride

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