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BS 181 dihydrochloride

Cat. No. 5608 Submit a Review Datasheet / COA / SDS
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Description: Selective cdk7 inhibitor
Chemical Name: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BS 181 dihydrochloride

BS 181 dihydrochloride is a selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over other cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

Compound Libraries for BS 181 dihydrochloride

BS 181 dihydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for BS 181 dihydrochloride

M. Wt 453.45
Formula C22H32N6.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1883548-83-1
PubChem ID 91826108
InChI Key XYXAMTBYYTXHSO-UHFFFAOYSA-N
Smiles CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BS 181 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.34 100
DMSO 45.34 100

Preparing Stock Solutions for BS 181 dihydrochloride

The following data is based on the product molecular weight 453.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.03 mL 22.05 mL
5 mM 0.44 mL 2.21 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets for BS 181 dihydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for BS 181 dihydrochloride

References are publications that support the biological activity of the product.

Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208 PMID: 19638587

If you know of a relevant reference for BS 181 dihydrochloride, please let us know.

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Citations for BS 181 dihydrochloride

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