Brivaracetam

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Cat.No. 7271 - Brivaracetam | C11H20N2O2 | CAS No. 357336-20-0
Description: SV2A ligand; antiepileptic
Chemical Name:S,4R)-α-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity for Brivaracetam

Brivaracetam is an antiepileptic compound that is a ligand for synaptic vesicle glycoprotein 2A (SV2A; Kd = 50 nM for human SV2A in vitro). Brivaracetam displays selectivity for SV2A at 10 μM, against a panel of 55 receptors, enzymes, ion channels and transporters. In mice, Brivaracetam protects against clonic audiogenic seizures.

Technical Data for Brivaracetam

M. Wt 212.29
Formula C11H20N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 357336-20-0
PubChem ID 9837243
InChI Key MSYKRHVOOPPJKU-BDAKNGLRSA-N
Smiles CCC[C@H]1CN(C(C1)=O)[C@H](C(N)=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Brivaracetam

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.23 100
water 21.23 100

Preparing Stock Solutions for Brivaracetam

The following data is based on the product molecular weight 212.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.71 mL 23.55 mL 47.11 mL
5 mM 0.94 mL 4.71 mL 9.42 mL
10 mM 0.47 mL 2.36 mL 4.71 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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References for Brivaracetam

References are publications that support the biological activity of the product.

Gillard et al (2011) Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties. Eur.J.Pharmacol. 664 36 PMID: 21575627

Rogawski (2016) A new SV2A ligand for epilepsy. Cell. 167 587 PMID: 27768878


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Keywords: Brivaracetam, Brivaracetam supplier, synaptic, vesicle, glycoprotein, 2A, SV2A, ligands, antiepileptic, Exocytosis, 7271, Tocris Bioscience

Citations for Brivaracetam

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