Pricing Availability   Qty
Description: SV2A ligand; antiepileptic
Chemical Name:S,4R)-α-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide
Purity: ≥98% (HPLC)

Biological Activity for Brivaracetam

Brivaracetam is an antiepileptic compound that is a ligand for synaptic vesicle glycoprotein 2A (SV2A; Kd = 50 nM for human SV2A in vitro). Brivaracetam displays selectivity for SV2A at 10 μM, against a panel of 55 receptors, enzymes, ion channels and transporters. In mice, Brivaracetam protects against clonic audiogenic seizures.

Technical Data for Brivaracetam

M. Wt 212.29
Formula C11H20N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 357336-20-0
PubChem ID 9837243
Smiles CCC[C@H]1CN(C(C1)=O)[C@H](C(N)=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Brivaracetam

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.23 100
water 21.23 100

Preparing Stock Solutions for Brivaracetam

The following data is based on the product molecular weight 212.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.71 mL 23.55 mL 47.11 mL
5 mM 0.94 mL 4.71 mL 9.42 mL
10 mM 0.47 mL 2.36 mL 4.71 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Brivaracetam

References are publications that support the biological activity of the product.

Gillard et al (2011) Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties. Eur.J.Pharmacol. 664 36 PMID: 21575627

Rogawski (2016) A new SV2A ligand for epilepsy. Cell. 167 587 PMID: 27768878

If you know of a relevant reference for Brivaracetam, please let us know.

View Related Products by Target

Keywords: Brivaracetam, Brivaracetam supplier, synaptic, vesicle, glycoprotein, 2A, SV2A, ligands, antiepileptic, Exocytosis, 7271, Tocris Bioscience

Citations for Brivaracetam

Citations are publications that use Tocris products.

Currently there are no citations for Brivaracetam. Do you know of a great paper that uses Brivaracetam from Tocris? Please let us know.

Reviews for Brivaracetam

There are currently no reviews for this product. Be the first to review Brivaracetam and earn rewards!

Have you used Brivaracetam?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review