BRD 7552

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Cat.No. 5230 - BRD 7552 | C33H33N3O15 | CAS No. 1137359-47-7
Description: PDX1 transcription factor inducer; increases insulin expression
Chemical Name: Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

PDX1 transcription factor inducer; up regulates PDX1 expression in both primary human islets and ductal cells. Induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. Increases insulin expression in PANC-1 cells, primary human islets and human duct-derived cells.

Technical Data

M. Wt 711.63
Formula C33H33N3O15
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1137359-47-7
PubChem ID 23891512
Smiles OC[C@@H]1[C@@H](OC(NC6=CC=C(C(OCC)=O)C=C6)=O)[C@H](OC(NC4=CC=C(OCO5)C5=C4)=O)[C@@H](OC(NC2=CC(OCO3)=C3C=C2)=O)[C@@H](OC)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 71.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 711.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.41 mL 7.03 mL 14.05 mL
5 mM 0.28 mL 1.41 mL 2.81 mL
10 mM 0.14 mL 0.7 mL 1.41 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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References are publications that support the biological activity of the product.

Yuan et al (2013) A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem.Biol. 20 1513 PMID: 24290880

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