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Submit ReviewBMY 45778
Description: Non-prostanoid prostacyclin IP receptor partial agonist
Chemical Name: [3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid
Purity: ≥99% (HPLC)
Biological Activity for BMY 45778
BMY 45778 is a non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC50 = 27-35 nM).
Licensing Information
Sold with the permission of Bristol-Myers Squibb Company
Technical Data for BMY 45778
| M. Wt | 438.44 |
| Formula | C26H18N2O5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 152575-66-1 |
| PubChem ID | 127861 |
| InChI Key | DSRSEEYZGWTODH-UHFFFAOYSA-N |
| Smiles | OC(=O)COC1=CC(=CC=C1)C1=C(N=CO1)C1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BMY 45778
References for BMY 45778
References are publications that support the biological activity of the product.
Meanwell et al (1993) Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid. 36 3884 PMID: 7504734
Rudd et al (2000) Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat: comparison of vagus nerve and NANC innervation of the colon. Br.J.Pharmacol. 129 782 PMID: 10683203
Seiler et al (1997) [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and ilo. binding. Prostaglandins 53 21 PMID: 9068064
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Keywords: BMY 45778, BMY 45778 supplier, Non-prostanoid, prostacyclin, IP1, receptor, partial, agonist, Receptors, Prostanoid, PGI, prostaglandins, prostacyclins, eicosanoids, BMY45778, 1442, Tocris Bioscience
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